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Marked reduction of Helicobacter pylori-induced gastritis by urease inhibitors, acetohydroxamic acid and flurofamide, in Mongolian gerbils
- Source :
- Biochemical and biophysical research communications. 285(3)
- Publication Year :
- 2001
-
Abstract
- Urease has been suggested to be essential for colonization and pathogenesis of Helicobacter pylori infection. In the present study, we evaluated the effects of urease inhibitors [acetohydroxamic acid (AHA) and flurofamide (FFA)] on H. pylori-induced gastritis in Mongolian gerbils. Animals were orally inoculated with H. pylori, and given urease inhibitors in their diet throughout the experimental period of six weeks or four weeks, starting from two weeks after H. pylori inoculation. With the administration of AHA at doses of 100, 500, and 2500 ppm throughout the experimental period, H. pylori-induced gastritis in animals was decreased in a dose-dependent manner, significantly so at 2500 ppm. Suppression of gastric lesions was also evident in animals administered 2500 ppm AHA after the H. pylori infection. Bacterial infection rates were reduced to 40-50% of the control value of 100%, by the highest dose of AHA. The potent urease inhibitor, FFA, also caused marked amelioration of H. pylori-associated gastritis on administration at 100 ppm throughout the six-week experimental period or for four weeks after H. pylori infection. Animals treated with FFA had few visible gastric lesions, and the proportion infected with H. pylori was reduced to less than 10%. Since antibiotic-resistant strains of H. pylori have become a serious problem, nonantibiotic urease inhibitors may be very useful to control H. pylori-associated gastroduodenal disease.
- Subjects :
- Male
Urease
Biophysics
Administration, Oral
Hydroxamic Acids
Biochemistry
Microbiology
Helicobacter Infections
Pathogenesis
Medicine
Animals
Enzyme Inhibitors
Molecular Biology
biology
Dose-Response Relationship, Drug
Helicobacter pylori
Inoculation
business.industry
Acetohydroxamic acid
Body Weight
Cell Biology
Organ Size
bacterial infections and mycoses
biology.organism_classification
Flurofamide
Dose–response relationship
Disease Models, Animal
Treatment Outcome
Gastritis
Benzamides
biology.protein
medicine.symptom
business
Gerbillinae
medicine.drug
Subjects
Details
- ISSN :
- 0006291X
- Volume :
- 285
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biochemical and biophysical research communications
- Accession number :
- edsair.doi.dedup.....4c82b047bf572186307e7f7ab02c39a9