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A Transplantable Syngeneic Allograft Mouse Model for Nongestational Choriocarcinoma of the Ovary
- Source :
- Vet Pathol
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- Nongestational choriocarcinoma is a rare malignancy in humans with poor prognosis. Naturally occurring choriocarcinoma is also rare in laboratory mice, and no genetic mouse model accurately recapitulates the features of this cancer. Here we report development of a genetically engineered mouse (GEM) model with alterations in Brca2, Trp53, and RB that develops ovarian tumors. Most of the ovarian tumors displayed histological characteristics of nongestational choriocarcinoma of the ovary (NGCO) (47%) with abundant syncytiotrophoblasts and cytotrophoblasts, positive immunolabeling for human chorionic gonadotropin, and positive periodic acid–Schiff reaction. The rest of the ovarian tumors were serous epithelial ovarian carcinoma (SEOC) (26%) or mixed tumors consisting of NGCO and SEOC (26%). We further established syngeneic orthotopic mouse models for NGCO by in vivo passaging of GEM tumors. These metastatic models provide a platform for evaluating new treatment strategies in preclinical studies aimed at improving outcomes in choriocarcinoma patients.
- Subjects :
- endocrine system
endocrine system diseases
Mice, Transgenic
Syncytiotrophoblasts
Ovary
Biology
Malignancy
Article
Human chorionic gonadotropin
Mice
03 medical and health sciences
0302 clinical medicine
medicine
Animals
reproductive and urinary physiology
030304 developmental biology
Ovarian Neoplasms
0303 health sciences
General Veterinary
Choriocarcinoma
Choriocarcinoma, Non-gestational
Cancer
Allografts
medicine.disease
female genital diseases and pregnancy complications
Disease Models, Animal
Serous fluid
medicine.anatomical_structure
030220 oncology & carcinogenesis
Genetically Engineered Mouse
embryonic structures
Cancer research
Female
Neoplasm Transplantation
Subjects
Details
- ISSN :
- 15442217 and 03009858
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Veterinary Pathology
- Accession number :
- edsair.doi.dedup.....4c79bc8ac6b5574a381adeb2383202a7