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Inhibiting or blocking LIGHT, a TNF superfamily member, for treating airway remodeling
- Publication Year :
- 2011
-
Abstract
- Evaluation of: Doherty TA, Soroosh P, Khorram N et al. The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling. Nat. Med. 17, 596–603 (2011).Individuals with chronic asthma demonstrate a progressive decline in lung function that is thought to be due to structural remodeling of the airways, characterized by subepithelial fibrosis and smooth muscle hyperplasia. Here we report on a recent publication showing that the tumor necrosis factor family member LIGHT is expressed on lung inflammatory cells after allergen exposure. Pharmacological inhibition of LIGHT using a fusion protein between the IgG Fc domain and lymphotoxin-β-receptor reduces lung fibrosis, smooth muscle hyperplasia and airway hyperresponsiveness in mouse models of chronic asthma, despite having little effect on airway eosinophilia. LIGHT-deficient mice also show a similar impairment in fibrosis and smooth muscle accumulation. Blockade of LIGHT suppresses expression of lung TGF-β and IL-13, cytokines implicated...
- Subjects :
- Pulmonary and Respiratory Medicine
Lung
business.industry
Settore MED/10 - Malattie dell'Apparato Respiratorio
Public Health, Environmental and Occupational Health
Smooth muscle hyperplasia
respiratory system
medicine.disease
respiratory tract diseases
Blockade
medicine.anatomical_structure
Fibrosis
Asthmatic Airway Remodeling
Immunology
medicine
Immunology and Allergy
Eosinophilia
Tumor necrosis factor alpha
medicine.symptom
Airway
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4c6f3d28ebf76b9a7282fae3049e997a