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The Effect of TGF-β2 on Dentin Apposition and Hardness in Transgenic Mice
- Source :
- Advances in Dental Research. 15:39-41
- Publication Year :
- 2001
- Publisher :
- SAGE Publications, 2001.
-
Abstract
- Transforming growth factor β, TGF-β, is expressed during tooth formation and can induce pre-odontoblast differentiation and formation of functional odontoblast-like cells in vitro. In addition, exogenous TGF-β can increase reparative dentin formation, presumably by acting on odontoblasts. In this study, we examined the tooth phenotype of transgenic mice, in which TGF-β2 expression is directed by the osteocalcin promoter. Previous studies have shown that these mice have a bone phenotype that resembles that of human osteoporosis, including the existence of spontaneous fractures. Microhardness testing of the enamel and dentin showed no differences in the molars of these transgenic mice as compared with those of their wild-type littermates. Consistent with the increase in bone mineral apposition rate previously reported in these mice, the dentin apposition rate appeared to be increased in the TGF-β2-overexpressing mice. Thus, in teeth, as in bone, TGF-β2 appears to stimulate the synthesis and deposition of matrix. Further studies are needed to understand the effect of TGF-β2 on distinct mineralized tissues (bone, dentin, and cementum) and to determine whether exogenous TGF-β2 may be useful for tooth repair.
- Subjects :
- Male
0301 basic medicine
Mineralized tissues
medicine.medical_specialty
Transgene
Osteocalcin
Mice, Transgenic
Matrix (biology)
Dentin, Secondary
Mice
Transforming Growth Factor beta2
03 medical and health sciences
Calcification, Physiologic
0302 clinical medicine
stomatognathic system
Hardness
Transforming Growth Factor beta
Internal medicine
Image Processing, Computer-Assisted
medicine
Dentin
Animals
Humans
Cementum
Cementogenesis
Dental Enamel
Promoter Regions, Genetic
Bone mineral
Odontoblasts
Chemistry
Cell Differentiation
030206 dentistry
General Medicine
Anatomy
Dentinogenesis
Disease Models, Animal
stomatognathic diseases
Apposition
Phenotype
030104 developmental biology
Endocrinology
Odontoblast
medicine.anatomical_structure
Osteoporosis
Tooth Calcification
Subjects
Details
- ISSN :
- 15440737 and 08959374
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Advances in Dental Research
- Accession number :
- edsair.doi.dedup.....4c4e47748fec5961944245e8e288c044