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Endomicroscopic analysis of time- and pressure-dependent area of subpleural alveoli in mechanically ventilated rats
- Source :
- Respiratory physiologyneurobiology. 203
- Publication Year :
- 2014
-
Abstract
- We investigated the effects of recruitment maneuvers on subpleural alveolar area in healthy rats. 36 mechanically ventilated rats were allocated to either ZEEP-group or PEEP – 5 cmH2O – group. The subpleural alveoli were observed using a transthoracal endoscopic imaging technique. Two consecutive low-flow maneuvers up to 30 cmH2O peak pressure each were performed, interrupted by 5 s plateau phases at four different pressure levels. Alveolar area change at maneuver peak pressures and during the plateau phases was calculated and respiratory system compliance before and after the maneuvers was analyzed. In both groups alveolar area at the second peak of the maneuver did not differ significantly compared to the first peak. During the plateau phases there was a slight increase in alveolar area. After the maneuvers, compliance increased by 30% in ZEEP group and 20% in PEEP group. We conclude that the volume insufflated by the low-flow recruitment maneuver is distributed to deeper but not to subpleural lung regions.
- Subjects :
- Pulmonary and Respiratory Medicine
Male
Physiology
Area change
Respiratory physiology
Plateau (mathematics)
Positive-Pressure Respiration
Endoscopic imaging
Medicine
Animals
Respiratory system
Rats, Wistar
Lung Compliance
Endoscopes
Analysis of Variance
Lung
business.industry
General Neuroscience
Pressure dependent
respiratory system
Respiration, Artificial
respiratory tract diseases
Rats
Compliance (physiology)
Pulmonary Alveoli
medicine.anatomical_structure
Anesthesia
Respiratory Mechanics
business
Lung Volume Measurements
Subjects
Details
- ISSN :
- 18781519
- Volume :
- 203
- Database :
- OpenAIRE
- Journal :
- Respiratory physiologyneurobiology
- Accession number :
- edsair.doi.dedup.....4c48df064f8fe197bc04f494de5ff979