Back to Search
Start Over
Quality Issues of Research Antibodies
- Source :
- Analytical Chemistry Insights, Vol 11 (2016), Analytical Chemistry Insights, Vol 2016, Iss 11, Pp 21-27 (2016), Analytical Chemistry Insights
- Publication Year :
- 2016
- Publisher :
- SAGE Publications, 2016.
-
Abstract
- According to several recent studies, an unexpectedly high number of landmark papers seem to be not reproducible by independent laboratories. Nontherapeutic antibodies used for research, diagnostic, food analytical, environmental, and other purposes play a significant role in this matter. Although some papers have been published offering suggestions to improve the situation, they do not seem to be comprehensive enough to cover the full complexity of this issue. In addition, no obvious improvements could be noticed in the field as yet. This article tries to consolidate the remarkable variety of conclusions and suggested activities into a more coherent conception. It is concluded that funding agencies and journal publishers need to take first and immediate measures to resolve these problems and lead the way to a more sustainable way of bioanalytical research, on which all can rely with confidence.
- Subjects :
- 0301 basic medicine
replication
Evidence-based practice
cross-reactivity
media_common.quotation_subject
lcsh:Analytical chemistry
Clinical science
Review
Bioinformatics
01 natural sciences
Biochemistry
Health informatics
Analytical Chemistry
03 medical and health sciences
reproducibility crisis
ligand binding assay
Medicine
Quality (business)
immunoassay
Medical journal
quality control
media_common
lcsh:QD71-142
irreproducibility
business.industry
010401 analytical chemistry
non-specific binding
selectivity
Public relations
paper retraction
0104 chemical sciences
Variety (cybernetics)
Medical Laboratory Technology
030104 developmental biology
monoclonal antibody
Informatics
immunochemistry
Cancer gene
business
Subjects
Details
- ISSN :
- 11773901
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Analytical Chemistry Insights
- Accession number :
- edsair.doi.dedup.....4c3f74f73985a7c52648cf69203086d8