Back to Search
Start Over
Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus
- Source :
- Angiology. 67(8)
- Publication Year :
- 2015
-
Abstract
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology. A major cause of morbidity and mortality in SLE is accelerated atherosclerosis. Endothelial-specific molecule 1 (endocan) is a potential predictor of vascular events and is expressed in response to inflammatory cytokines in endothelial cells. We investigated the relationship between endocan and carotid intima–media thickness (cIMT) as a marker of early atherosclerosis. We included 44 women with SLE and 44 healthy women as controls. Disease severity of SLE was evaluated using the SLE Disease Activity Index. Endocan, C-reactive protein, erythrocyte sedimentation rate (ESR), and lipid panel were measured. The cIMT was 0.70 (range: 0.45-1.20) mm in patients with SLE and 0.40 (0.25-0.60) mm in controls ( P < .001). Endocan value was 1.6 ± 0.9 ng/mL in controls and 2.2 ± 1.0 ng/mL in patients with SLE ( P = .014). Endocan levels were positively correlated with cIMT ( r = .469, P < .001), body mass index ( r = .373, P = .013), and ESR ( r = .393, P = .008). Endocan level may be associated with subclinical atherosclerosis in SLE. Consequently, endocan levels may be a promising clinical tool for patients with SLE as a guide for preventive strategy.
- Subjects :
- Adult
Carotid Artery Diseases
Inflammation
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
Severity of Illness Index
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
immune system diseases
medicine
Humans
Lupus Erythematosus, Systemic
In patient
Prospective Studies
skin and connective tissue diseases
030203 arthritis & rheumatology
Autoimmune disease
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
Neoplasm Proteins
Up-Regulation
Cross-Sectional Studies
Erythrocyte sedimentation rate
Subclinical atherosclerosis
Case-Control Studies
Immunology
Asymptomatic Diseases
Etiology
Female
Proteoglycans
medicine.symptom
Inflammation Mediators
Cardiology and Cardiovascular Medicine
business
Body mass index
Biomarkers
Subjects
Details
- ISSN :
- 19401574
- Volume :
- 67
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Angiology
- Accession number :
- edsair.doi.dedup.....4c3b59287870d1d4507496efecac43b1