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Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)
- Source :
- J Dent Res
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- Microbial communities along mucosal surfaces throughout the digestive tract are hypothesized as risk factors for impaired glucose regulation and the development of clinical cardiometabolic disease. We investigated whether baseline measures of subgingival microbiota predicted fasting plasma glucose (FPG) longitudinally. The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS) enrolled 230 diabetes-free adults (77% female) aged 20 to 55 y (mean ± SD, 34 ± 10 y) from whom baseline subgingival plaque and longitudinal FPG were measured. DNA was extracted from subgingival plaque, and V3 to V4 regions of the 16S rRNA gene were sequenced. FPG was measured at baseline and again at 2 y; glucose change was defined as follow-up minus baseline. Multivariable linear models regressed 2-y glucose change onto baseline measures of community diversity and abundances of 369 individual taxa. A microbial dysbiosis index (MDI) summarizing top individual taxa associated with glucose change was calculated and used in regression models. Models were adjusted for age, sex, race/ethnicity, education, smoking status, body mass index, and baseline glucose levels. Statistical significance was based on the false discovery rate (FDR; -4, derived from the initial 369 hypothesis tests for specific taxa. Mean 2-y FPG change was 1.5 ± 8 mg/dL. Baseline levels of 9 taxa predicted FPG change (all FDR -4). Subgingival microbiota predict 2-y glucose change among diabetes-free men and women.
- Subjects :
- Adult
Blood Glucose
Male
0301 basic medicine
Diabetes risk
Atopobium
Gingiva
Physiology
Infections
Young Adult
03 medical and health sciences
0302 clinical medicine
Insulin resistance
RNA, Ribosomal, 16S
Statistical significance
Glucose Intolerance
Diabetes Mellitus
medicine
Humans
General Dentistry
Periodontitis
biology
business.industry
Microbiota
Research Reports
030206 dentistry
Middle Aged
medicine.disease
biology.organism_classification
Glucose
030104 developmental biology
Female
Blood sugar regulation
Digestive tract
Insulin Resistance
business
Body mass index
Subjects
Details
- ISSN :
- 15440591 and 00220345
- Volume :
- 98
- Database :
- OpenAIRE
- Journal :
- Journal of Dental Research
- Accession number :
- edsair.doi.dedup.....4c2b4a3e6e2beeec04f71b12063a0064