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Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
- Source :
- Science. 325:161-165
- Publication Year :
- 2009
- Publisher :
- American Association for the Advancement of Science (AAAS), 2009.
-
Abstract
- Toward Drug Development The vast majority of pharmaceuticals on the market are based on natural product molecules originally derived from living organisms. When it comes to newly approved drugs, however, the situation looks rather different. Difficulties with high-throughput screening and laboratory synthesis of natural products have led drug companies to focus on libraries of synthetic compounds, despite their providing a much lower “hit rate.” Li and Vederas (p. 161 ) review methodologies that facilitate the screening, analysis, and synthesis of natural product molecules and their derivatives. Given these advances and the vast numbers of organisms and environments that remain to be explored for potential drug candidates, the current lull in newly approved drugs based on natural products will likely be temporary.
- Subjects :
- Resource (biology)
Drug Industry
Drug Evaluation, Preclinical
New Drug Approvals
Natural (archaeology)
chemistry.chemical_compound
Synthetic biology
Drug Discovery
Animals
Combinatorial Chemistry Techniques
Technology, Pharmaceutical
Drug Approval
Pharmaceutical industry
Biological Products
Multidisciplinary
Natural product
Bacteria
Molecular Structure
business.industry
Drug discovery
Plants
Data science
Biotechnology
Drug development
chemistry
Drug Design
business
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 325
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....4c23bebb9ff2dc82ec73170dc0c270f3