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Restoring ion channel pathology by parameter optimization
- Source :
- BMC Neuroscience, BMC Neuroscience, Vol 12, Iss Suppl 1, p P334 (2011)
- Publication Year :
- 2011
- Publisher :
- BioMed Central, 2011.
-
Abstract
- In diseases of the brain, the distribution and properties of ion channels display deviations from healthy control subjects. We studied two cases of ion channel alterations related to epileptogenesis. The first case of ion channel alteration represents an enhanced sodium current, the second case addresses the run down of conductance of the transient potassium current, KA. In previous studies we have shown that KA reduce highly synchronized synaptic input while minimally affect semi-synchronized input (1). The KA channel may therefore function as a protective mechanism against synchronous input involved in seizures. In this study we investigate if modulatory substances which targets the KA can functionally corrected the two pathological models.
- Subjects :
- Computer science
General Neuroscience
lcsh:QP351-495
Conductance
Epileptogenesis
Sodium current
lcsh:RC321-571
Potassium current
Cellular and Molecular Neuroscience
lcsh:Neurophysiology and neuropsychology
Healthy control
Poster Presentation
Transient (oscillation)
Neuroscience
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Ion channel
Communication channel
Subjects
Details
- Language :
- English
- ISSN :
- 14712202
- Volume :
- 12
- Issue :
- Suppl 1
- Database :
- OpenAIRE
- Journal :
- BMC Neuroscience
- Accession number :
- edsair.doi.dedup.....4c035903f43fc81e52ab12291404dba9