Back to Search
Start Over
Early-life chronic di(2-ethylhexyl)phthalate exposure worsens age-related long-term associative memory decline associated with insulin/IGF-1 signaling and CRH-1/CREB in Caenorhabditis elegans
- Source :
- Journal of Hazardous Materials. 417:126044
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The ubiquitous contamination of di(2-ethylhexyl)phthalate (DEHP) in the environment, biota, and food poses potential ecological and human health risks. DEHP exposure can adversely affect learning and memory, yet the underlying mechanisms remain unclear. In this study, Caenorhabditis elegans was used to investigate the effect of early-life DEHP exposure on age-related long-term associative memory (LTAM) decline, as well as the associations with the cAMP-responsive element-binding protein (CREB) transcription factor and insulin/IGF-1 signaling (IIS). We showed that early-life exposure to DEHP reduced LTAM in wild-type worms at day-0 adulthood. Chronic exposure to DEHP from the L1 stage to day-5 adulthood worsened the age-dependent decline of LTAM. Moreover, the effect of DEHP on age-related LTAM requires CRH-1, a homolog of CREB. Mutations in daf-2, the sole receptor of C. elegans IIS, ameliorated the inhibition of LTAM by DEHP, and the effect depended on daf-16. In addition, daf-2 mutation restored the CRH-1 level in DEHP-exposed worms, and the effect required daf-16. Our study suggests that early-life chronic exposure to DEHP worsens age-related LTAM decline and the effect is associated with CRH-1 and IIS in C. elegans. The evolutionary conservation of IIS and CREB implies possible adverse effects by DEHP across species.
- Subjects :
- Adult
endocrine system
medicine.medical_specialty
Environmental Engineering
Health, Toxicology and Mutagenesis
medicine.medical_treatment
medicine.disease_cause
CREB
chemistry.chemical_compound
Diethylhexyl Phthalate
Internal medicine
medicine
Animals
Humans
Insulin
Environmental Chemistry
Insulin-Like Growth Factor I
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Receptor
Waste Management and Disposal
Transcription factor
Memory Disorders
Mutation
biology
Phthalate
biology.organism_classification
Pollution
Endocrinology
chemistry
biology.protein
Transcription Factors
Hormone
Subjects
Details
- ISSN :
- 03043894
- Volume :
- 417
- Database :
- OpenAIRE
- Journal :
- Journal of Hazardous Materials
- Accession number :
- edsair.doi.dedup.....4bf8ef9e88814d2909724b4a813ce5bd