Laryngeal contact granuloma

Objective: To report outcomes of treatment for laryngeal contact granuloma. Study Design: Prospective treatment of 21 patients with laryngeal contact granulomas using proton-pump inhibitor (PPI) medication. Methods: Patients were diagnosed and followed by office endoscopy and patient interview. Results: Three patients did not tolerate PPI medication and were managed by treatment with type 2 histamine (H 2 ) blockers. The lesion completely resolved in 14 of the 18 patients maintained on PPI medication, and significantly regressed in the other 4. Residual granulomas were surgically excised in one patient. Lesions resolved in two patients following injection of botulinum toxin into one thyroarytenoid muscle. One patient had a residual lesion, but symptoms were controlled by medication, and he declined treatment with botulinum toxin. Of the three patients treated with H 2 -blocker medication, the lesion resolved in only one. Conclusion: PPI medication is effective in the treatment of laryngeal contact granuloma, even in the absence of identifiable symptoms of gastroesophageal reflux.