Back to Search
Start Over
Bone marrow‐derived mesenchymal stem cells inhibit CD8(+) T cell immune responses via PD‐1/PD‐L1 pathway in multiple myeloma
- Source :
- Clin Exp Immunol
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Summary High expression of the inhibitory receptor programmed cell death ligand 1 (PD-L1) on tumor cells and tumor stromal cells have been found to play a key role in tumor immune evasion in several human malignancies. However, the expression of PD-L1 on bone marrow mesenchymal stem cells (BMSCs) and whether the programmed cell death 1 (PD-1)/PD-L1 signal pathway is involved in the BMSCs versus T cell immune response in multiple myeloma (MM) remains poorly defined. In this study, we explored the expression of PD-L1 on BMSCs from newly diagnosed MM (NDMM) patients and the role of PD-1/PD-L1 pathway in BMSC-mediated regulation of CD8+ T cells. The data showed that the expression of PD-L1 on BMSCs in NDMM patients was significantly increased compared to that in normal controls (NC) (18·81 ± 1·61 versus 2·78± 0·70%; P
- Subjects :
- 0301 basic medicine
Adult
CD4-Positive T-Lymphocytes
Male
Stromal cell
T cell
Immunology
Programmed Cell Death 1 Receptor
CD8-Positive T-Lymphocytes
B7-H1 Antigen
Granzymes
03 medical and health sciences
0302 clinical medicine
Immune system
Bone Marrow
medicine
Immunology and Allergy
Cytotoxic T cell
Humans
Aged
Aged, 80 and over
Chemistry
Perforin
Mesenchymal stem cell
Immunity
Mesenchymal Stem Cells
Original Articles
Middle Aged
Thalidomide
Granzyme B
Killer Cells, Natural
030104 developmental biology
medicine.anatomical_structure
Cancer research
Female
Tumor Escape
Bone marrow
Multiple Myeloma
CD8
030215 immunology
Signal Transduction
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clin Exp Immunol
- Accession number :
- edsair.doi.dedup.....4bed60f97dae6c6e0e291838c1ed3722