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Hyperhomocysteinemia is an independent risk factor of atherosclerosis in patients with metabolic syndrome
- Source :
- Diabetology & Metabolic Syndrome, Diabetology & Metabolic Syndrome, Vol 11, Iss 1, Pp 1-9 (2019)
- Publication Year :
- 2019
-
Abstract
- Background Metabolic syndrome (MetS) is a clinical condition potentially promoting the development of atherosclerotic disease. To date, the clinical impact of elevated serum homocysteine (Hcy) levels in MetS is still under discussion. The aim of this cross sectional study was to evaluate the relationship between MetS and hyperhomocysteinemia and the potential role of Hcy in the pathogenesis of atherosclerotic complications of MetS. Methods We recruited 300 outpatients with MetS. All patients underwent a medical history collection, physical examination, blood sampling and carotid ultrasound echo-color Doppler. According to Hcy levels, MetS patients were divided into two groups: “normal” ( Results Patients with high Hcy were predominantly male and slightly older than group 1 patients. Smokers and non-smokers exhibited similar Hcy levels, nor was a statistical relationship between pack-years and Hcy observed. Group 2 showed lower levels of folic acid, vitamin D, high density lipoprotein (HDL)-cholesterol and glomerular filtration rate (e-GFR) than group 1, but higher levels of C-peptide, uric acid and triglycerides. In all patients, Hcy was positively correlated with C-peptide and uric acid and negatively with folic acid and e-GFR. Intima-media thickness (IMT) and carotid stenosis degree were significantly higher in patients with high Hcy and a positive relationship between Hcy and both IMT and carotid stenosis was detected in all patients. Finally, Hcy atherogenic effects were independent of other well-known atherosclerosis risk factors. Conclusions Our results highlight a link between MetS and hyperhomocysteinemia and a direct effect of Hcy on atherogenic process during MetS. Early correction of folic acid levels may contribute to prevent cardiovascular complications in MetS patients.
- Subjects :
- medicine.medical_specialty
Hyperhomocysteinemia
Homocysteine
Folic acid
Endocrinology, Diabetes and Metabolism
Pack-years
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Internal medicine
Diabetes mellitus
Internal Medicine
Carotid stenosis
Medicine
Risk factor
lcsh:RC620-627
IMT
business.industry
Research
medicine.disease
Metabolic syndrome
lcsh:Nutritional diseases. Deficiency diseases
chemistry
Uric acid
C-peptide
business
030217 neurology & neurosurgery
Blood sampling
Subjects
Details
- ISSN :
- 17585996
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Diabetologymetabolic syndrome
- Accession number :
- edsair.doi.dedup.....4bea4ba3ce62dc58c527dde1b4151649