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An experimental study of lung lesions caused by extracellular enzyme of streptomyces thermohygroscopicus
- Source :
- Journal of Tongji Medical University. 11:10-14
- Publication Year :
- 1991
- Publisher :
- Springer Science and Business Media LLC, 1991.
-
Abstract
- Rabbits and rats were infected intratracheally with extracellular enzyme of Streptomyces thermohygroscopicus (H9-4) by only one exposure, and lesions of the lung developed including mononuclear macrophage infiltration as well as bronchitis and vasculitis. The obvious damages in type I pneumocytes, endothelial cells of capillaries and arterioles in the lung were observed by electron microscopy. Immunofluorescent histochemistry examination revealed exudation of plasma fibronectin which might play an important role during the process of lesion repairing in lung. The experiment also confirmed that extracellular enzyme of Streptomyces thermohygroscopicus might directly damage the lung tissue. These experimental data may serve as valuable reference for studying the etiology and pathogenesis of farmer's lung disease.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Pathogenesis
Lesion
Management of Technology and Innovation
medicine
Extracellular
Animals
Type-I Pneumocytes
Lung
biology
Farmer's lung
Rats, Inbred Strains
respiratory system
medicine.disease
Streptomyces
Fibronectins
Rats
respiratory tract diseases
Fibronectin
medicine.anatomical_structure
Farmer's Lung
biology.protein
Immunohistochemistry
Female
Rabbits
medicine.symptom
Subjects
Details
- ISSN :
- 0257716X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Tongji Medical University
- Accession number :
- edsair.doi.dedup.....4bdd754cc37e604a3b97f9e66a06715f