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Cyclin D1 overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer
- Source :
- British Journal of Cancer
- Publication Year :
- 1999
- Publisher :
- Nature Publishing Group, 1999.
-
Abstract
- Cyclin D1 is one of the G1 cyclins that control cell cycle progression by allowing G1 to S transition. Overexpression of cyclin D1 has been postulated to play an important role in the development of human cancers. We have investigated the correlation between cyclin D1 overexpression and known clinicopathological factors and also its prognostic implication on resected non-small-cell lung cancer (NSCLC) patients. Formalin-fixed and paraffin-embedded tumour tissues resected from 69 NSCLC patients between stages I and IIIa were immunohistochemically examined to detect altered cyclin D1 expression. Twenty-four cases (34.8%) revealed positive immunoreactivity for cyclin D1. Cyclin D1 overexpression is significantly higher in patients with lymph node metastasis (50.0% vs 14.4%, P = 0.002) and with advanced pathological stages (I, 10%; II, 53.8%; IIIa, 41.7%, P = 0.048; stage I vs II, IIIa, P = 0.006). Twenty-four patients with cyclin D1-positive immunoreactivity revealed a significantly shorter overall survival than the patients with negativity (24.0 ± 3.9 months vs 50.1 ± 6.4 months, P = 0.0299). Among 33 patients between stages I and II, nine patients with cyclin D1-positive immunoreactivity had a much shorter overall survival (29.7 ± 6.1 months vs 74.6 ± 8.6 months, P = 0.0066). These results suggest that cyclin D1 overexpression is involved in tumorigenesis of NSCLCs from early stage and could be a predictive molecular marker for poor prognosis in resectable NSCLC patients, which may help us to choose proper therapeutic modalities after resection of the tumor. © 1999 Cancer Research Campaign
- Subjects :
- Adult
Male
Cancer Research
Lung Neoplasms
cyclin D1
Biology
medicine.disease_cause
Cyclin D1
Carcinoma, Non-Small-Cell Lung
Proliferating Cell Nuclear Antigen
medicine
Biomarkers, Tumor
Humans
Stage (cooking)
Lung cancer
Pathological
Cyclin
Aged
Respiratory disease
Regular Article
Middle Aged
medicine.disease
Prognosis
Immunohistochemistry
Survival Analysis
Oncology
non-small-cell lung cancer
Multivariate Analysis
Cancer research
Female
progression
Carcinogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 15321827 and 00070920
- Volume :
- 81
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....4bd85d716c9d583da1113fe1e41da9e1