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Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group, 2020.
-
Abstract
- In the past decade, the high morbidity and mortality of atherosclerotic disease have been prevalent worldwide. High-fat food consumption has been suggested to be an overarching factor for atherosclerosis incidence. This study aims to investigate the effects of kefir peptides on high-fat diet (HFD)-induced atherosclerosis in apolipoprotein E knockout (ApoE−/−) mice. 7-week old male ApoE−/− and normal C57BL/6 mice were randomly divided into five groups (n = 8). Atherosclerotic lesion development in ApoE−/− mice was established after fed the HFD for 12 weeks compared to standard chow diet (SCD)-fed C57BL/6 and ApoE−/− control groups. Kefir peptides oral administration significantly improved atherosclerotic lesion development by protecting against endothelial dysfunction, decreasing oxidative stress, reducing aortic lipid deposition, attenuating macrophage accumulation, and suppressing the inflammatory immune response compared with the HFD/ApoE−/− mock group. Moreover, the high dose of kefir peptides substantially inhibited aortic fibrosis and restored the fibrosis in the aorta root close to that observed in the C57BL/6 normal control group. Our findings show, for the first time, anti-atherosclerotic progression via kefir peptides consumption in HFD-fed ApoE−/− mice. The profitable effects of kefir peptides provide new perspectives for its use as an anti-atherosclerotic agent in the preventive medicine.
- Subjects :
- 0301 basic medicine
Apolipoprotein E
Male
medicine.medical_specialty
Mice, Knockout, ApoE
THP-1 Cells
Administration, Oral
lcsh:Medicine
030204 cardiovascular system & hematology
medicine.disease_cause
Diet, High-Fat
Article
Inflammasome
Lesion
03 medical and health sciences
Mice
0302 clinical medicine
Immune system
Kefir
Oral administration
Fibrosis
Internal medicine
medicine
Animals
Humans
Endothelial dysfunction
lcsh:Science
Multidisciplinary
business.industry
Macrophages
lcsh:R
medicine.disease
Atherosclerosis
Lipid Metabolism
Oxidative Stress
030104 developmental biology
Endocrinology
Knockout mouse
lipids (amino acids, peptides, and proteins)
lcsh:Q
medicine.symptom
business
Peptides
Oxidative stress
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....4bd37fc80c6507872f8b0cc02854fb58