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CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8
- Source :
- Immunology Letters, Hansen, A S, Slater, J, Biltoft, M, Bundgaard, B B, Møller, B K & Höllsberg, P 2018, ' CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells ', Immunology Letters, vol. 200, pp. 26-32 . https://doi.org/10.1016/j.imlet.2018.06.003
- Publication Year :
- 2018
-
Abstract
- Highlights • Activation of CD46 induces rapid down-modulation of CD46 expression on the surface of CD8+ T cells. • CD46 co-stimulation potently induces CD8+ T cell proliferation. • CD46 co-stimulation does not induce a switch to IL-10 production in CD8+ T cells, as is known for CD4+ T cells. • CD46 co-stimulation predominantly expands IFN-γ-producing CD8+ T cells.<br />Similar to CD4+ T cells, precursor CD8+ T cells are thought to depend on a co-stimulatory signal through CD28 for proliferation and differentiation into effector cells. CD46 is another co-stimulatory receptor that promotes differentiation of CD4+ T-helper cells type 1 (Th1 cells) into a regulatory phenotype with a switch from IFN-γ towards IL-10-secretion over time. Whether CD46 exerts a similar function on CD8+ T cells remains to be fully elucidated. Here, we demonstrate that CD46 co-stimulation induced secretion of IFN-γ as well as expansion of IFN-γ-secreting CD8+ T cells. In contrast to CD46 co-stimulation of CD4+ T cells, CD8+ T cells did not differentiate into a regulatory IL-10-secreting phenotype. This demonstrates that CD46 is a co-stimulatory receptor on CD8+ T cells, and that it exerts separate functions during CD4+ and CD8+ T-cell differentiation.
- Subjects :
- 0301 basic medicine
PBMC, peripheral blood mononuclear cell
viruses
Immunology
Proliferation
CD8-Positive T-Lymphocytes
Lymphocyte Activation
Article
Immunophenotyping
Membrane Cofactor Protein
03 medical and health sciences
Interferon-gamma
0302 clinical medicine
T-Lymphocyte Subsets
Immunology and Allergy
Cytotoxic T cell
Humans
Secretion
Receptor
CD46
IFN-γ
Chemistry
Effector
Th1 cells, T-helper cells type 1
CD28
Phenotype
female genital diseases and pregnancy complications
Cell biology
CD8+T cells
Interleukin 10
030104 developmental biology
TCR, T-cell receptor
IL-10
Cytokines
CD8
Biomarkers
030215 immunology
Subjects
Details
- ISSN :
- 18790542
- Volume :
- 200
- Database :
- OpenAIRE
- Journal :
- Immunology letters
- Accession number :
- edsair.doi.dedup.....4bcab20691da84aa1d6d0a5ac3c8123e