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Ketamine Protects Gamma Oscillations by Inhibiting Hippocampal LTD
- Source :
- PLoS ONE, Vol 11, Iss 7, p e0159192 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- NMDA receptors have been widely reported to be involved in the regulation of synaptic plasticity through effects on long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD have been implicated in learning and memory processes. Besides synaptic plasticity, it is known that the phenomenon of gamma oscillations is critical in cognitive functions. Synaptic plasticity has been widely studied, however it is still not clear, to what degree synaptic plasticity regulates the oscillations of neuronal networks. Two NMDA receptor antagonists, ketamine and memantine, have been shown to regulate LTP and LTD, to promote cognitive functions, and have even been reported to bring therapeutic effects in major depression and Alzheimer’s disease respectively. These compounds allow us to investigate the putative interrelationship between network oscillations and synaptic plasticity and to learn more about the mechanisms of their therapeutic effects. In the present study, we have identified that ketamine and memantine could inhibit LTD, without impairing LTP in the CA1 region of mouse hippocampus, which may underlie the mechanism of these drugs’ therapeutic effects. Our results suggest that NMDA-induced LTD caused a marked loss in the gamma power, and pretreatment with 10 μM ketamine prevented the oscillatory loss via its inhibitory effect on LTD. Our study provides a new understanding of the role of NMDA receptors on hippocampal plasticity and oscillations.
- Subjects :
- Male
0301 basic medicine
Nonsynaptic plasticity
lcsh:Medicine
Hippocampus
Mice
Learning and Memory
0302 clinical medicine
Medicine and Health Sciences
Long-term depression
lcsh:Science
Long-Term Synaptic Depression
Multidisciplinary
Synaptic scaling
Organic Compounds
Chemistry
Monosaccharides
Brain
Neurodegenerative Diseases
Long-term potentiation
Animal Models
Synaptic Potentials
Neurology
Anesthesia
Physical Sciences
Ketamine
Anatomy
Research Article
Computer and Information Sciences
Neural Networks
Carbohydrates
Mouse Models
Research and Analysis Methods
03 medical and health sciences
Model Organisms
Developmental Neuroscience
Memantine
Alzheimer Disease
Mental Health and Psychiatry
Metaplasticity
Animals
Homosynaptic plasticity
Organic Chemistry
lcsh:R
Chemical Compounds
Biology and Life Sciences
Mice, Inbred C57BL
Glucose
030104 developmental biology
nervous system
Cellular Neuroscience
Synaptic plasticity
Cognitive Science
Dementia
lcsh:Q
Neuroscience
030217 neurology & neurosurgery
Synaptic Plasticity
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....4bc958afd263cfb25a1b084eb8f6b036