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Association of shear-wave elastography with clinical outcomes post-liver transplantation
- Source :
- Clinics and Research in Hepatology and Gastroenterology, Clinics and Research in Hepatology and Gastroenterology, 2021, 45 (5), pp.101554. ⟨10.1016/j.clinre.2020.09.015⟩
- Publication Year :
- 2020
-
Abstract
- Purpose Two-dimensional shear-wave elastography (2D-SWE) assessment of liver stiffness has the advantage of being obtained during conventional ultrasound. Liver-stiffness values on 2D-SWE for grafted livers are unknown, as are their potential link to post-transplantation morbidity. This study was undertaken to determine liver-stiffness values on 2D-SWE for grafted livers without complications, and examine relationships between liver-stiffness values on 2D-SWE and early post-operative arterial or biliary complications. Methods In our facility, all liver-transplant recipients are entered in a comprehensive surgical database, where donor, procedure and recipient characteristics are described. All patients underwent systematic 2D-SWE assessment. Potential relationships were analyzed between liver-stiffness findings and donor, procedure and recipient characteristics, and follow-up events, including death, arterial or biliary complications, graft removal and allograft-dysfunction scores. Results Liver-stiffness values on 2D-SWE of 337 ultrasound examinations from 165 liver-transplant recipients were collected retrospectively. Median time from transplantation to 2D-SWE examination was 149 days, with median follow-up at 36 months. The mean ± SD stiffness value for grafts without complications was 7.3 ± 2.3 kPa; it was significantly higher during the first 90 days (8.2 ± 2.5 kPa) post-transplant than after 1 year (7.0 ± 2.4 kPa) (P = 0.01). Patients with biliary complications during the first-year post-transplantation had significantly higher mean liver-stiffness values on 2D-SWE than those without, respectively: 9.8 ± 7.0 vs 7.5 ± 1.8 kPa (P = 0.01). Conclusions Post-transplantation patients without complications had stiffer livers than the general population, with higher values during the first 90 days after surgery. Liver-stiffness values on 2D-SWE were significantly higher for patients with biliary, but not arterial, complications.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Population
Liver transplantation
Conventional ultrasound
03 medical and health sciences
0302 clinical medicine
Liver stiffness
medicine
Humans
Bile ducts
education
Ultrasonography
Retrospective Studies
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph]
Shear wave elastography
education.field_of_study
Hepatology
medicine.diagnostic_test
business.industry
Ultrasound
Gastroenterology
End-stage liver disease
Surgery
Liver Transplantation
Transplantation
Treatment Outcome
Liver
030220 oncology & carcinogenesis
Elasticity Imaging Techniques
030211 gastroenterology & hepatology
Elastography
business
Subjects
Details
- ISSN :
- 2210741X and 22107401
- Volume :
- 45
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Clinics and research in hepatology and gastroenterology
- Accession number :
- edsair.doi.dedup.....4bc1138d6e7f413038fd26c48fef6e6e