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Prostatic ischemia induces ventral prostatic hyperplasia in the SHR; possible mechanism of development of BPH
- Source :
- Scientific Reports
- Publication Year :
- 2013
-
Abstract
- In the light of increasing evidence that benign prostatic hyperplasia is associated with cardiovascular disease, we have investigated the relationship between prostatic blood flow and prostatic hyperplasia in the spontaneously-hypertensive-rat (SHR). Twelve-week-old male SHRs were treated with nicorandil for six weeks. Wistar-Kyoto rats were used as controls. Six weeks after nicorandil treatment, blood pressure and the prostatic blood flow were estimated and tissue levels of malondialdehyde, HIF-1α, TGF-β1, bFGF, dihydrotestosterone and α-SMA were measured. SHRs showed significant increases in blood pressure, tissue levels of malondialdehyde, HIF-1α, TGF-β1, bFGF, α-SMA and a significant decrease in the prostatic blood flow. Although treatment with nicorandil failed to alter the blood-pressure and α-SMA, it significantly ameliorated the increased levels of malondialdehyde, HIF-1α, TGF-β1 and bFGF. There were no significant differences in tissue levels of dihydrotestosterone among any groups. These data indicate that development of prostatic hyperplasia may be associated with prostatic hypoxia, which nicorandil prevents via its effect to increase the blood flow.
- Subjects :
- Male
medicine.medical_specialty
Ischemia
Prostatic Hyperplasia
Blood Pressure
Enzyme-Linked Immunosorbent Assay
Rats, Inbred WKY
Article
Transforming Growth Factor beta1
chemistry.chemical_compound
Internal medicine
Malondialdehyde
Rats, Inbred SHR
medicine
Animals
Nicorandil
Multidisciplinary
business.industry
Prostate
Dihydrotestosterone
Blood flow
Hypoxia (medical)
Hyperplasia
medicine.disease
Hypoxia-Inducible Factor 1, alpha Subunit
Actins
Rats
Oxidative Stress
Endocrinology
Blood pressure
chemistry
Regional Blood Flow
Hypertension
cardiovascular system
Fibroblast Growth Factor 2
medicine.symptom
business
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....4bbcf79a468963d091ec508b9f945cb9