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Treatment of Vitamin D Deficiency in Cystic Fibrosis
- Publication Year :
- 2015
-
Abstract
- Vitamin D deficiency occurs frequently in patients with cystic fibrosis (CF). Vitamin D is important for optimal mineralization of bone and may be important for other comorbidities commonly occurring in patients with CF. Vitamin D deficiency in patients with CF can arise from various causes including pancreatic exocrine insufficiency, lack of outdoor activity, and alterations of vitamin D metabolism. Due to fat malabsorption stemming from pancreatic insufficiency, higher oral doses of vitamin D are necessary to correct and maintain optimal vitamin D status in patients with CF. Recent studies have demonstrated that higher vitamin D status is associated with better lung function and that vitamin D therapy may help recovery from pulmonary exacerbations of CF. The mechanisms by which vitamin D may exert its beneficial actions in CF are unclear but likely related to the role vitamin D has in modulating the adaptive and innate immune response. Large randomized clinical studies to evaluate the potential role of vitamin D as adjunctive therapy in CF that goes beyond bone are necessary.
- Subjects :
- medicine.medical_specialty
Cystic Fibrosis
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
030209 endocrinology & metabolism
Inflammation
Comorbidity
Biochemistry
Cystic fibrosis
vitamin D deficiency
Article
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
medicine
Vitamin D and neurology
Humans
In patient
Vitamin D
Molecular Biology
Lung
Cholecalciferol
Randomized Controlled Trials as Topic
Clinical Trials as Topic
Innate immune system
business.industry
Pancreatic exocrine insufficiency
Cell Biology
medicine.disease
Vitamin D Deficiency
Fat malabsorption
Respiratory Function Tests
030228 respiratory system
Ergocalciferols
Molecular Medicine
medicine.symptom
Bone Diseases
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....4bb1493c777a58bbffdad6dc80b0603e