Supplementary Figure 1 from Targeted Mutations in the ATR Pathway Define Agent-Specific Requirements for Cancer Cell Growth and Survival

PDF file - 74K, Effect of CDK2 on DNA replication fork dynamics. Replicating DNA was sequentially labeled with CIdU (red) and IdU (green), and the length of double-labeled DNA fibers were measured via confocal microscopy. (A) Distribution of fork rates in unperturbed HCT116 cells and the CDK2-/- derivative cell line. (B) Average fork rates in HCT116 parental and CDK2-/- cells. ** denotes significance (One-tailed paired Student's t-test, p