Back to Search
Start Over
A six-herb Chinese medicine composition ointment as a promising candidate for treatment of hypertrophic scars
- Source :
- Chinese herbal medicines. 13(2)
- Publication Year :
- 2020
-
Abstract
- Objective To study the anti-hypertrophic scar effect of the six-herb Chinese medicine composition (SCMC) ointment on the rabbit ear hypertrophic scar models. Methods The optimal formulation of SCMC ointment matrix was screened by the orthogonal designs and a series of evaluation tests. The SCMC ointment was prepared through emulsifying method. The rabbit ear hypertrophic scar models were established and used to investigate the anti-hypertrophic scar effect of SCMC ointment. Results Our results demonstrated that all the quality control indications of the SCMC ointment met the requirements. Anti-hypertrophic scar activity results showed that all the rabbit ear scar tissues appeared different degrees of shrink and fading, and took an unobvious but palpable shift from hard to soft texture with the low, middle and high concentration SCMC ointments treatments in vivo. Additionally, on 21st day the scar area and thickness in different concentrations of SCMC ointment groups were significantly reduced than control group, in a concentration-dependent manner. The immunohistochemical results also indicated that the SCMC ointment had good anti-hypertrophic scar properties and could inhibit hypertrophic scar formation. Conclusion The SCMC ointment could improve the blood circulation condition of hypertrophic scar tissues. Our research has demonstrated the Chinese medicine composition ointment with good anti-hypertrophic scar properties that could be used to treat hypertrophic scars. Meanwhile, it provides a theoretical basis for further clinical application.
- Subjects :
- medicine.medical_specialty
food.ingredient
Scar tissue
Traditional Chinese medicine
030226 pharmacology & pharmacy
01 natural sciences
03 medical and health sciences
Hypertrophic scar
0302 clinical medicine
food
Ophthalmology
Medicine
Pharmacology (medical)
Pharmacology
High concentration
business.industry
medicine.disease
eye diseases
0104 chemical sciences
stomatognathic diseases
010404 medicinal & biomolecular chemistry
Complementary and alternative medicine
Herb
Blood circulation
Hypertrophic scars
business
Subjects
Details
- ISSN :
- 25893610
- Volume :
- 13
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Chinese herbal medicines
- Accession number :
- edsair.doi.dedup.....4ba1c1c4ed0b7d160a566b31edafb2c1