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Developmental immunotoxicity is not associated with the consumption of transgenic Bt rice TT51 in rats
- Source :
- Regulatory Toxicology and Pharmacology. 94:197-202
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- TT51 is a transgenic strain of Bt rice generated by fusing a synthetic CryAb/Ac gene into MingHui rice. In this study, rats from F0, F1, and F2 generations were fed a diet with 60% TT51 rice, MingHui rice, or nominal-origin rice. The study focused on developmental immunotoxicity in F1 and F2 offspring after long-term consumption of TT51. A wide range of immunological parameters was monitored in this two-generation study on reproductive toxicity. The experiments were performed on F1 and F2 offspring at postnatal days 21 and 42. No adverse clinical effects were observed in any of the experimental groups. In addition, histopathology observations and immunotoxicity tests, including hematological indicators, spleen lymphocyte subsets, natural killer cell activity, lymphoproliferative response, and plaque-forming cell assay, revealed no significant difference between the groups. These results indicated that developmental immunotoxicity was not associated with a diet of transgenic Bt rice TT51, compared to the parental MingHui rice.
- Subjects :
- Male
medicine.medical_specialty
Food Safety
Offspring
Transgene
Cell Count
Hemolytic Plaque Technique
Spleen
Biology
Toxicology
Andrology
0404 agricultural biotechnology
Pregnancy
medicine
Animals
Lymphocytes
Rats, Wistar
Maternal-Fetal Exchange
Gene
Cell Proliferation
Reproduction
Strain (biology)
food and beverages
Oryza
04 agricultural and veterinary sciences
General Medicine
Plants, Genetically Modified
040401 food science
Diet
Killer Cells, Natural
medicine.anatomical_structure
Female
Histopathology
Reproductive toxicity
Lymphoproliferative response
Subjects
Details
- ISSN :
- 02732300
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Regulatory Toxicology and Pharmacology
- Accession number :
- edsair.doi.dedup.....4b9ada823d6b8c155c1833578f193ab2