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Symmetrical palatal fibromatosis: An additional case report with immunohistochemical characterization
- Source :
- Journal of Clinical and Experimental Dentistry, Caldeira, P., da Silva, K., Vasconcelos, A. C., Souto, G., & Mesquita, R. (2021). Symmetrical palatal fibromatosis: An additional case report with immunohistochemical characterization. Journal of clinical and experimental dentistry, 13(4), e422–e425.
- Publication Year :
- 2021
- Publisher :
- Medicina Oral S.L., 2021.
-
Abstract
- Background The term "symmetrical palatal fibromatosis" was recently suggested to designate bilateral palatal lesions presenting as typically broad, "mirror" images on the posterior lateral region of the hard palate. Purpose We report an additional case of this as-yet poorly understood oral lesion in a 67-year-old male patient, with emphasis on differential diagnoses and immunohistochemical characterization. Case Report The histopathological examination demonstrated a hypocellular, fibrous connective tissue with prominent thick collagen bundles and few blood vessels. Scattered large, stellate, and sometimes binucleated fibroblasts were found. Immunohistochemistry was positive for vimentin and negative for smooth muscle actin, S-100, desmin, HHF-35, AE1-AE3, Factor XIIIa, CD68, and FOSL1. This is the second study to show the immunohistochemical profile, with emphasis in FOSL1, of an additional case of symmetrical palatal fibromatosis. Conclusions We encourage further reports about this entity, especially in relation to immunohistochemical and molecular features, so far poorly described, but very important for better recognition of this entity. Key words:Palate, symmetrical palatal fibromatosis, desmoplastic fibroblastoma, immunohistochemistry.
- Subjects :
- Pathology
medicine.medical_specialty
Oral Medicine and Pathology
biology
business.industry
CD68
Fibromatosis
Vimentin
Case Report
medicine.disease
Lesion
medicine.anatomical_structure
biology.protein
Medicine
Immunohistochemistry
Desmin
Hard palate
medicine.symptom
business
General Dentistry
Desmoplastic fibroblastoma
UNESCO:CIENCIAS MÉDICAS
Subjects
Details
- Language :
- English
- ISSN :
- 19895488
- Volume :
- 13
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical and Experimental Dentistry
- Accession number :
- edsair.doi.dedup.....4b975aefab62d294eede09bcaf661423