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Short-term TPN containing n-3 fatty acids ameliorate lactic acidosis induced by endotoxin in guinea pigs
- Source :
- The American Journal of Clinical Nutrition. 52:548-552
- Publication Year :
- 1990
- Publisher :
- Elsevier BV, 1990.
-
Abstract
- We evaluated the effect of total parenteral nutrition (TPN) enriched with n-3 fatty acids on the physiologic response to endotoxin in guinea pigs. Animals were randomly assigned to receive TPN differing only in lipid source for 3.5 d. Group 1 received soybean fat emulsion (Intralipid) whereas group 2 received fish (menhaden) oil. During the last 7 h of TPN, animals were further randomized to have either saline or E coli endotoxin added to the infusate. Acid-base status and serum lactate concentrations were determined. Animals infused with soybean fat emulsions and endotoxin developed a significant metabolic acidosis, lactic acidemia, and decrease in mixed venous O2 compared with controls and fish-oil-treated animals (p less than 0.05). The significantly reduced serum lactate and higher mixed venous O2 in fish-oil-infused animals suggests that the underlying mechanism involves improvement in endotoxin-induced tissue hypoperfusion, presumably through alterations in prostaglandin metabolism.
- Subjects :
- Fat Emulsions, Intravenous
medicine.medical_specialty
medicine.medical_treatment
Guinea Pigs
Medicine (miscellaneous)
Caviidae
Fish Oils
Internal medicine
Fatty Acids, Omega-3
medicine
Animals
Saline
Acid-Base Equilibrium
Nutrition and Dietetics
biology
business.industry
Menhaden
Metabolic acidosis
Metabolism
Hydrogen-Ion Concentration
biology.organism_classification
Fish oil
medicine.disease
Endotoxins
Oxygen
Endocrinology
Parenteral nutrition
Biochemistry
Lactic acidosis
Lactates
Acidosis, Lactic
Parenteral Nutrition, Total
Blood Gas Analysis
business
Subjects
Details
- ISSN :
- 00029165
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- The American Journal of Clinical Nutrition
- Accession number :
- edsair.doi.dedup.....4b92bebfcfcb29672378560245d7f692