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The relation between superoxide dismutase in cancer tissue and clinico pathological features in breast cancer
- Source :
- Breast Cancer. 4:155-160
- Publication Year :
- 1997
- Publisher :
- Springer Science and Business Media LLC, 1997.
-
Abstract
- The localization of Cu/Zn- and Mn-superoxide dismutase (SOD) in breast cancer tissue (12 papillotubular carcinomas, 21 solid-tubular carcinomas, 16 scirrhous carcinomas, 1 medullary carcinoma, 1 secreting carcinoma, 1 lobular carcinoma, 1 Paget’s disease) was investigated via an immunohistochemical technique using antihuman Cu/Zn- and Mn-SOD antibodies in 10% formalin fixed-paraffin embedded thin sections. Both SODs stained strongly in the normal breast gland, but not clearly in many cancer tissues. Furthermore, Cu/Zn-SOD stained more strongly in well differentiated tubular carcinomas than in poorly differentiated tubular carcinomas. It tended to stain less in tumors which recurred or had a poor outcome, and in tumors with a diploid pattern on DNA flow cytometry. Mn-SOD staining was similar to that of Cu/Zn-SOD, but no significant differences among subgroups was found, since the incidence of positively staining tumors was too small in all groups. The intensity of SOD staining seems to change in relation to cell proliferation and differentiation in breast carcinoma, and may be a prognostic indicator, since SOD decreased in poorly differentiated carcinoma and in tumors which developed distant metastasis. Thus, the localization of SOD in breast cancer tissue can provide useful information for cancer treatment.
- Subjects :
- Pathology
medicine.medical_specialty
business.industry
Lobular carcinoma
Cancer
General Medicine
medicine.disease
Breast cancer
Oncology
Medullary carcinoma
Surgical oncology
Carcinoma
medicine
Immunohistochemistry
Pharmacology (medical)
Radiology, Nuclear Medicine and imaging
business
Breast carcinoma
Subjects
Details
- ISSN :
- 18804233 and 13406868
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Breast Cancer
- Accession number :
- edsair.doi.dedup.....4b8e75bfec32b19d3dc50d4f3e7fad20
- Full Text :
- https://doi.org/10.1007/bf02967069