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Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians
- Source :
- Journal of Diabetes and its Complications. 24:115-120
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Aim The objective of this study is to assess the contribution of ADIPOQ variants to type 2 diabetes in Japanese Brazilians. Methods We genotyped 200 patients with diabetes mellitus (100 male and 100 female, aged 55.0 years [47.5–64.0 years]) and 200 control subjects with normal glucose tolerant (NGT) (72 male and 128 female, aged 52.0 years [43.5–64.5 years]). Results Whereas each polymorphism studied (T45G, G276T, and A349G) was not significantly associated with type 2 diabetes mellitus, the haplotype GGA was overrepresented in our diabetic population (9.3% against 3.1% in NGT individuals, P =.0003). Also, this haplotype was associated with decreased levels of adiponectin. We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. The subjects carrying the R221S mutation had plasma adiponectin levels lower than those without the mutation (2.10 μg/ml [1.35–2.55 μg/ml] vs. 6.68 μg/ml [3.90–11.23 μg/ml], P =.015). Similarly, the I164T mutation carriers had mean plasma adiponectin levels lower than those noncarriers (3.73 μg/ml [3.10–4.35 μg/ml] vs. 6.68 μg/ml [3.90–11.23 μg/ml]), but this difference was not significant ( P =.17). Conclusions We identified in the ADIPOQ gene a risk haplotype for type 2 diabetes in the Japanese Brazilian population.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Population
Type 2 diabetes
ADIPOQ Gene
Body Mass Index
Endocrinology
Asian People
Japan
Polymorphism (computer science)
Internal medicine
Diabetes mellitus
Internal Medicine
Humans
Medicine
education
education.field_of_study
Polymorphism, Genetic
Adiponectin
business.industry
Haplotype
Type 2 Diabetes Mellitus
Middle Aged
medicine.disease
Diabetes Mellitus, Type 2
Haplotypes
Mutation
Female
business
Brazil
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 10568727
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes and its Complications
- Accession number :
- edsair.doi.dedup.....4b8db9d9c366097cf0bf80ae91147b73