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Highly variable suicidal ideation: a phenotypic marker for stress induced suicide risk
- Source :
- Molecular psychiatry
- Publication Year :
- 2020
-
Abstract
- Suicidal behavior (SB) can be impulsive or methodical; violent or not; follow a stressor or no obvious precipitant. This study tested whether childhood trauma, affective lability, and aggressive and impulsive traits predicted greater SI variability. We also assessed whether affective lability, aggressive or impulsive traits explain childhood trauma’s effects on SI variability and whether those with highly variable SI respond to stressful events with increases in SI. Finally, we assessed variable SI’s trajectory over 2 years. Depressed participants (n = 51) had ecological momentary assessments (EMA) over 7 days at baseline, 3, 6, 12, 18, and 24 months. SI variability was assessed using the square Root of the Mean Square of Successive Deviations. Mixed Effects Models were fit as appropriate. Childhood trauma was associated with subsequent aggression. Physical abuse predicted both aggression and affective lability as well as SI variability, but not impulsivity. In two-predictor models, physical abuse’s effect on SI variability was no longer significant, when controlling for the effect of higher aggression and impulsivity. Those with high SI variability exhibited greater increases in SI after stressors compared with those with less variability. We did not find that SI variability changed over time, suggesting it might be trait-like, at least over 2 years. Variable SI predisposes to marked SI increases after stressful events and may be a trait increasing risk for impulsive SB, at least over 2 years.
- Subjects :
- 0301 basic medicine
Suicide, Attempted
Impulsivity
Article
Suicidal Ideation
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Risk Factors
medicine
Humans
Suicide Risk
Molecular Biology
Suicidal ideation
Lability
business.industry
Aggression
Stressor
Psychiatry and Mental health
Suicide
030104 developmental biology
Physical abuse
Impulsive Behavior
Trait
medicine.symptom
business
030217 neurology & neurosurgery
Biomarkers
Clinical psychology
Subjects
Details
- Language :
- English
- ISSN :
- 14765578 and 13594184
- Volume :
- 26
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Molecular psychiatry
- Accession number :
- edsair.doi.dedup.....4b8897dfd111658532b30065d50783ba