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Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG
- Source :
- Journal of Neuroimmunology, Journal of Neuroimmunology, 320, 19-24
- Publication Year :
- 2018
-
Abstract
- Immunoglobulin G (IgG) harbors a conserved N-glycosylation site which is important for its effector functions. Changes in glycosylation of IgG occur in many autoimmune diseases but also in physiological conditions. Therefore, the glycosylation pattern of serum IgG is well characterized. However, limited data is available on the glycosylation pattern of IgG in cerebrospinal fluid (CSF) compared to serum. Here, we report significantly reduced levels of bisected glycans in CSF IgG. Galactosylation and sialylation of IgG4 also differed significantly. Therefore, we propose a common mechanism mediating glycosylation changes of IgG at the transition from serum to CSF in steady state conditions.
- Subjects :
- Male
0301 basic medicine
Serum
Glycan
animal structures
Glycosylation
Immunology
Clinical Neurology
macromolecular substances
Sialylation
Immunoglobulin G
03 medical and health sciences
chemistry.chemical_compound
Cerebrospinal fluid
Polysaccharides
Humans
Immunology and Allergy
ddc:610
Effector functions
Aged
Aged, 80 and over
Transition (genetics)
biology
Chemistry
Middle Aged
Bisecting
3. Good health
carbohydrates (lipids)
030104 developmental biology
Neurology
biology.protein
Female
lipids (amino acids, peptides, and proteins)
Neurology (clinical)
Subjects
Details
- ISSN :
- 01655728
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroimmunology
- Accession number :
- edsair.doi.dedup.....4b8189f97c21fdafb83cd6caa46f4b67
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2018.04.010