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Impulse oscillometry at preschool age is a strong predictor of lung function by flow-volume spirometry in adolescence
- Source :
- Pediatric Pulmonology. 53:552-558
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Background The transition from early childhood wheezing to persistent asthma is linked to lung function impairment over time. Little is known how the methods used to study lung function at different ages correlate longitudinally. Methods Sixty-four children with a history of hospitalization for bronchiolitis before 6 months of age were prospectively studied with impulse oscillometry (IOS) at the mean age of 6.3 years and these preschool IOS results were compared with flow-volume spirometry (FVS) measurements at mean age of 11.4 years. Results The baseline respiratory system resistance at 5 Hz (Rrs5) showed a modest statistically significant correlation with all baseline FVS parameters except FVC. The post-bronchodilator (post-BD) Rrs5 showed a modest statistically significant correlation with post-BD FEV1 and FEV1 /FVC. The bronchodilator-induced decrease in Rrs5 showed a modest statistically significant correlation with the percent increase in FEV1 . Baseline and post-BD respiratory reactance at 5 Hz (Xrs5) showed a modest statistically significant correlation with baseline and post-BD FVS parameters except post-BD FEV1 /FVC, respectively, and post-BD Xrs5 showed a strong correlation with post-BD FVC (ρ = 0.61) and post-BD FEV1 (ρ = 0.59). In adjusted linear regression, preschool Xrs5 remained as a statistically significant independent predictor of FVS parameters in adolescence; the one-unit decrease in the Z-score of preschool post-BD Xrs5 predicted 9.6% lower post-BD FEV1 , 9.3% lower post-BD FVC, and 9.7% lower post-BD MEF50 when expressed as %-predicted parameters. Conclusion Persistent post-BD small airway impairment in children with a history of bronchiolitis detected with IOS at preschool age predicted FVS results measured in early adolescence.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Spirometry
medicine.medical_specialty
Time Factors
Pulmonary function testing
Correlation
03 medical and health sciences
FEV1/FVC ratio
0302 clinical medicine
Predictive Value of Tests
Forced Expiratory Volume
Oscillometry
Internal medicine
Linear regression
medicine
Humans
Prospective Studies
030212 general & internal medicine
Respiratory system
Child
medicine.diagnostic_test
business.industry
respiratory system
medicine.disease
ta3123
Asthma
respiratory tract diseases
Impulse Oscillometry
030228 respiratory system
Bronchiolitis
Child, Preschool
Pediatrics, Perinatology and Child Health
Cardiology
Female
business
Subjects
Details
- ISSN :
- 87556863
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Pediatric Pulmonology
- Accession number :
- edsair.doi.dedup.....4b7a774ad64cf7ff921eaf1c63a8613e