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Clinical characteristics associated with increased wound size in patients with recessive dystrophic epidermolysis bullosa

Authors :
Daniel Solis
Claudia Teng
Ying Lu
M. Peter Marinkovich
J. Nazaroff
Andrew M. Subica
Shufeng Li
Emily S. Gorell
Jean Y. Tang
M. Barriga
Source :
Pediatric Dermatology.
Publication Year :
2021
Publisher :
Wiley, 2021.

Abstract

As more therapeutic clinical trials focus on treatment of individual wounds in patients with recessive dystrophic epidermolysis bullosa, it has become crucial to understand the baseline clinical characteristics of these wounds. To investigate these features, we administered an RDEB-specific wound survey. Forty participants reported on location, size, pain, infection frequency, wound type, and duration of 189 wounds; a subset of 22 participants reported on pruritus in 63 wounds. Increased wound size was significantly associated with increased pain, increased pruritus, longer wound duration, increased infection frequency, and patients with mutations resulting in truncated type VII collagen.

Details

ISSN :
15251470 and 07368046
Database :
OpenAIRE
Journal :
Pediatric Dermatology
Accession number :
edsair.doi.dedup.....4b79e67b2d36c675fc7878698c22798c
Full Text :
https://doi.org/10.1111/pde.14576