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Clinical characteristics associated with increased wound size in patients with recessive dystrophic epidermolysis bullosa
- Source :
- Pediatric Dermatology.
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- As more therapeutic clinical trials focus on treatment of individual wounds in patients with recessive dystrophic epidermolysis bullosa, it has become crucial to understand the baseline clinical characteristics of these wounds. To investigate these features, we administered an RDEB-specific wound survey. Forty participants reported on location, size, pain, infection frequency, wound type, and duration of 189 wounds; a subset of 22 participants reported on pruritus in 63 wounds. Increased wound size was significantly associated with increased pain, increased pruritus, longer wound duration, increased infection frequency, and patients with mutations resulting in truncated type VII collagen.
- Subjects :
- Wound Healing
medicine.medical_specialty
Collagen Type VII
integumentary system
business.industry
Wound size
Dermatology
medicine.disease
Epidermolysis Bullosa Dystrophica
Clinical trial
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Type VII collagen
030220 oncology & carcinogenesis
Mutation
Pediatrics, Perinatology and Child Health
Recessive dystrophic epidermolysis bullosa
Humans
Medicine
In patient
Epidermolysis bullosa
business
Wound healing
Subjects
Details
- ISSN :
- 15251470 and 07368046
- Database :
- OpenAIRE
- Journal :
- Pediatric Dermatology
- Accession number :
- edsair.doi.dedup.....4b79e67b2d36c675fc7878698c22798c
- Full Text :
- https://doi.org/10.1111/pde.14576