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Impact on Longevity of Genetic Cardiovascular Risk and Lifestyle including Red Meat Consumption
- Source :
- Oxidative Medicine and Cellular Longevity, Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Background. Cardiovascular risk (CVR) underlies aging process and longevity. Previous work points to genetic and environmental factors associated with this risk.Objectives. The aim of this research is to look for any CVR gene-gene and gene-multifactorial/lifestyle interactions that may impact health and disease and underlie exceptional longevity.Methods. A case-control study involving 521 both gender individuals, 253 centenarians (100.26±1.98years), and 268 controls (67.51±3.25years), low (LCR,n=107) and high (HCR,n=161) CVR. Hypertension, diabetes, obesity (BMI, kg·m-2), and impaired kidney function were defined according to standard criteria. CVR was calculated using Q risk®. DNA was genotyping (ACE-rs4646994,AGT-rs4762,AGR1-rs5182,GRK4-rs2960306,GRK4-rs1024323,NOS3-rs1799983, andSLC12A3-rs13306673) through iPlex-MassARRAY®, read by MALDI-TOF mass spectrometry, and analyzed by EARTDECODE®.Results. Antilongevity factors consisted (OR 95% CI,p<0.05) BMI 1.558 (1.445-1.680), hypertension 2.358 (1.565-3.553), smoking habits 4.528 (2.579-7.949), diabetes 5.553 (2.889-10.675), hypercholesterolemia 1.016 (1.010-1.022), and regular consumption of red meat 22.363 (13.987-35.755). Genetic aspects particularly for HCR individualsACEII (OR: 3.96 (1.83-8.56),p<0.0001) andNOS3TT (OR: 3.11 (1.70-5.70),p<0.0001) genotypes were also risk associate. Obesity, smoking, hypercholesterolemia, and frequent consumption of red meat have an additive action to hypertension in the longevity process. There was a synergistic interaction between the endothelialNOS3genotypes and the severity of arterial hypertension. An epistatic interaction between functional genetic variants ofGRK4and angiotensinogen was also observed.Conclusions.Cardiovascular risk-related genetic and multifactorial or predominantly lifestyle aspects and its interactions might influence the aging process and contribute to exceptional longevity in Portuguese centenarians. Besides lifestyle, the activity of nitrite oxide synthase may be one of the main physiologic regulators of cardiovascular protection in the path of longevity.
- Subjects :
- Male
0301 basic medicine
Aging
Article Subject
media_common.quotation_subject
Longevity
Physiology
Renal function
Disease
030204 cardiovascular system & hematology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Genotype
medicine
Humans
Life Style
media_common
QH573-671
business.industry
Cell Biology
General Medicine
medicine.disease
Obesity
Red Meat
030104 developmental biology
Cardiovascular Diseases
Heart Disease Risk Factors
Red Meat Consumption
Case-Control Studies
Red meat
Female
Cytology
business
Research Article
Subjects
Details
- ISSN :
- 19420994 and 19420900
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.doi.dedup.....4b73bf42acc53449014db18b05ca54d2