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Structure of the Mouse Calcitonin/Calcitonin Gene-Related Peptide Alpha and Beta Genes
- Source :
- DNA Sequence. 12:131-135
- Publication Year :
- 2001
- Publisher :
- Informa UK Limited, 2001.
-
Abstract
- We report the cloning, genomic organization and sequence of the mouse alpha-CALC and beta-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the alpha-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the beta-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse alpha-CGRP was found to be identical to rat alpha-CGRP, however, beta-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.
- Subjects :
- Calcitonin
Genetics
chemistry.chemical_classification
Base Sequence
Calcitonin Gene-Related Peptide
Molecular Sequence Data
Sequence Homology
Biology
Calcitonin gene-related peptide
Biochemistry
Molecular biology
Amino acid
Mice
Exon
Endocrinology
Sequence homology
chemistry
Transcription (biology)
Animals
Molecular Biology
Gene
Genomic organization
Subjects
Details
- ISSN :
- 10425179
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- DNA Sequence
- Accession number :
- edsair.doi.dedup.....4b56b6a4fa35868d7e74f43de48dc560