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Hip Osteoarthritis in Dogs: A Randomized Study Using Mesenchymal Stem Cells from Adipose Tissue and Plasma Rich in Growth Factors
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences 15(8), 13437-13460 (2014), Helvia. Repositorio Institucional de la Universidad de Córdoba, instname, International Journal of Molecular Sciences; Volume 15; Issue 8; Pages: 13437-13460, International Journal of Molecular Sciences, Vol 15, Iss 8, Pp 13437-13460 (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI, 2014.
-
Abstract
- Purpose: The aim of this study was to compare the efficacy and safety of a single intra-articular injection of adipose mesenchymal stem cells (aMSCs) versus plasma rich in growth factors (PRGF) as a treatment for reducing symptoms in dogs with hip osteoarthritis (OA). Methods: This was a randomized, multicenter, blinded, parallel group. Thirty-nine dogs with symptomatic hip OA were assigned to one of the two groups, to receive aMSCs or PRGF. The primary outcome measures were pain and function subscales, including radiologic assessment, functional limitation and joint mobility. The secondary outcome measures were owners’ satisfaction questionnaire, rescue analgesic requirement and overall safety. Data was collected at baseline, then, 1, 3 and 6 months post-treatment. Results: OA degree did not vary within groups. Functional limitation, range of motion (ROM), owner’s and veterinary investigator visual analogue scale (VAS), and patient’s quality of life improved from the first month up to six months. The aMSCs group obtained better results at 6 months. There were no adverse effects during the study. Our findings show that aMSCs and PRGF are safe and effective in the functional analysis at 1, 3 and 6 months; provide a significant improvement, reducing dog’s pain, and improving physical function. With respect to basal levels for every parameter in patients with hip OA, aMSCs showed better results at 6 months.
- Subjects :
- Male
Time Factors
hip
Adipose tissue
Osteoarthritis
Osteoarthritis, Hip
law.invention
lcsh:Chemistry
Randomized controlled trial
Quality of life
law
Medicine
Range of Motion, Articular
lcsh:QH301-705.5
Spectroscopy
adipose derived mesenchymal stem cells
General Medicine
Computer Science Applications
Plasma rich in growth factors
Adipose Tissue
dog
Intercellular Signaling Peptides and Proteins
Female
Range of motion
medicine.medical_specialty
Visual analogue scale
Analgesic
Mesenchymal Stem Cell Transplantation
Catalysis
Article
Inorganic Chemistry
Dogs
plasma rich in growth factors
Internal medicine
Animals
osteoarthritis
Physical and Theoretical Chemistry
Adverse effect
Molecular Biology
Hip
business.industry
Organic Chemistry
Mesenchymal Stem Cells
medicine.disease
Surgery
lcsh:Biology (General)
lcsh:QD1-999
Adipose derived mesenchymal stem cells
business
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 15
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....4b503941c7d1a3f2e171c012c11d6150