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Hip Osteoarthritis in Dogs: A Randomized Study Using Mesenchymal Stem Cells from Adipose Tissue and Plasma Rich in Growth Factors

Authors :
Mónica Rubio
Jose M. Vilar
Belén Cuervo
José M. Carrillo
Juan M. Domínguez
Ramón Cugat
Joaquin Sopena
Manuel Morales
Source :
International Journal of Molecular Sciences, International Journal of Molecular Sciences 15(8), 13437-13460 (2014), Helvia. Repositorio Institucional de la Universidad de Córdoba, instname, International Journal of Molecular Sciences; Volume 15; Issue 8; Pages: 13437-13460, International Journal of Molecular Sciences, Vol 15, Iss 8, Pp 13437-13460 (2014)
Publication Year :
2014
Publisher :
MDPI, 2014.

Abstract

Purpose: The aim of this study was to compare the efficacy and safety of a single intra-articular injection of adipose mesenchymal stem cells (aMSCs) versus plasma rich in growth factors (PRGF) as a treatment for reducing symptoms in dogs with hip osteoarthritis (OA). Methods: This was a randomized, multicenter, blinded, parallel group. Thirty-nine dogs with symptomatic hip OA were assigned to one of the two groups, to receive aMSCs or PRGF. The primary outcome measures were pain and function subscales, including radiologic assessment, functional limitation and joint mobility. The secondary outcome measures were owners’ satisfaction questionnaire, rescue analgesic requirement and overall safety. Data was collected at baseline, then, 1, 3 and 6 months post-treatment. Results: OA degree did not vary within groups. Functional limitation, range of motion (ROM), owner’s and veterinary investigator visual analogue scale (VAS), and patient’s quality of life improved from the first month up to six months. The aMSCs group obtained better results at 6 months. There were no adverse effects during the study. Our findings show that aMSCs and PRGF are safe and effective in the functional analysis at 1, 3 and 6 months; provide a significant improvement, reducing dog’s pain, and improving physical function. With respect to basal levels for every parameter in patients with hip OA, aMSCs showed better results at 6 months.

Details

Language :
English
ISSN :
14220067
Volume :
15
Issue :
8
Database :
OpenAIRE
Journal :
International Journal of Molecular Sciences
Accession number :
edsair.doi.dedup.....4b503941c7d1a3f2e171c012c11d6150