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Haplotypic association of DDAH1 with susceptibility to pre-eclampsia
- Source :
- MHR: Basic science of reproductive medicine. 11:73-77
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- Association between pre-eclampsia (PEE1) and the dimethylarginine dimethylaminohydrolase (DDAH) 1 and 2 genes, which play a role in the regulation of nitric oxide synthesis and release, was studied. In a case –control study design single nucleotide polymorphisms (SNPs) were determined at eight sites in the DDAH1 gene and at one site (Pro231Pro) in the DDAH2 gene from 132 women with pre-eclampsia and 112 healthy controls. Three SNPs in the DDAH1 gene were associated with preeclampsia, showing complete linkage disequilibrium with each other, but none of the associations in the allele or genotype data reached statistical significance in either of the genes after the correction for multiple testing. Haplotype frequencies were estimated using a population based on a maximum likelihood method (EM algorithm). Four common DDAH1 haplotypes were present and a significant association of haplotypes H2 and H3 with pre-eclampsia (P 5 0.03) was found. The risk of pre-eclampsia was greatest in individuals (odds ratio: 3.93; 95% confidence interval: 1.54 –9.99) who had two copies of the high-risk haplotypes (H2 or H3). The observed haplotypic association provides the first evidence of the importance of DDAH1 polymorphisms in pre-eclampsia susceptibility.
- Subjects :
- Adult
Embryology
Linkage disequilibrium
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Linkage Disequilibrium
Amidohydrolases
Pre-Eclampsia
Pregnancy
Genotype
Genetics
Humans
Genetic Predisposition to Disease
Allele
Molecular Biology
Finland
Likelihood Functions
Haplotype
Obstetrics and Gynecology
Cell Biology
Odds ratio
Confidence interval
Haplotypes
Reproductive Medicine
Case-Control Studies
Multiple comparisons problem
Female
Developmental Biology
Subjects
Details
- ISSN :
- 14602407 and 13609947
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- MHR: Basic science of reproductive medicine
- Accession number :
- edsair.doi.dedup.....4b47df84e3da15bd18efd287ecf6c7d3