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The anti-cancer properties of heparin and its derivatives: a review and prospect
- Source :
- Cell Adhesion & Migration, article-version (VoR) Version of Record, Cell Adhesion & Migration, Vol 14, Iss 1, Pp 118-128 (2020)
- Publication Year :
- 2020
-
Abstract
- Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase, P-/L-selectin, angiogenesis, and interference with the CXCL12-CXCR4 axis. Here we summarize the current experimental evidence regarding the anti-cancer role of heparin and its derivatives, and conclude that there is evidence to support heparin’s role in inhibiting cancer progression, making it a promising anti-cancer agent.
- Subjects :
- 0301 basic medicine
medicine.drug_class
Low molecular weight heparin
Angiogenesis Inhibitors
Antineoplastic Agents
Review
Pharmacology
Metastasis
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Medicine
Animals
Humans
cancer
metastasis
lcsh:QH573-671
low-molecular-weight heparin
Glucuronidase
Lymphatic Vessels
business.industry
lcsh:Cytology
Heparin
heparin derivatives
Cancer
Cell Biology
medicine.disease
030104 developmental biology
030220 oncology & carcinogenesis
Neoplastic Stem Cells
business
Venous thromboembolism
medicine.drug
Subjects
Details
- ISSN :
- 19336926
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cell adhesionmigration
- Accession number :
- edsair.doi.dedup.....4b1a9668e4cc265d7250f69da14c6d68