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Peculiarities of the Formation of Antimeningococcus Immunity in Mice Immunized with Fragments of N. meningitidis IgA1 Protease
- Source :
- Bulletin of Experimental Biology and Medicine. 165:763-766
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- We studied immunogenicity of two recombinant proteins FR.9 and FR.11-3 created on the basis of fragments of the primary structure of N. meningitidis IgA1 protease with different molecular weights containing different sets of T and B epitopes. The proteins actively protect animals infected with live virulent culture of meningococci, serogroups A, B, and C. Analysis of CD4+, CD8+, and CD19+ lymphocyte populations in mouse blood showed predominant contribution of different cell populations to the formation of immune response to different proteins. Injection of FR.11-3 protein to animals did no affect the immunoregulatory index, hence, this protein can be used for creation of immunologically safe vaccine preparation.
- Subjects :
- CD4-Positive T-Lymphocytes
0301 basic medicine
Lymphocyte
Antigens, CD19
Virulence
CD8-Positive T-Lymphocytes
Neisseria meningitidis
Biology
Serogroup
General Biochemistry, Genetics and Molecular Biology
CD19
Epitope
Microbiology
Epitopes
Mice
03 medical and health sciences
Immune system
Bacterial Proteins
Immunity
medicine
Animals
B-Lymphocytes
Mice, Inbred BALB C
Immunogenicity
Serine Endopeptidases
General Medicine
Recombinant Proteins
Meningococcal Infections
Molecular Weight
030104 developmental biology
medicine.anatomical_structure
biology.protein
Immunization
CD8
Subjects
Details
- ISSN :
- 15738221 and 00074888
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- Bulletin of Experimental Biology and Medicine
- Accession number :
- edsair.doi.dedup.....4b18cc9f835a46bba0d80ad1a5a3d511