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Priming B cell-mediated anti-HIV envelope responses by vaccination allows for the long-term control of infection in macaques exposed to a R5-tropic SHIV
- Source :
- Virology. 320(1):167-180
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- The potential of vaccine-elicited anti-HIV envelope antibodies to control HIV-infection was evaluated by immunizing macaques with the HIV envelope protein and transiently depleting them of their CD8+ cells before intravenous challenge with the pathogenic CCR5-tropic SIV/HIV chimeric virus, SHIVSF162P4. Although sterilizing immunity was not achieved, all vaccinated animals effectively controlled infection and remained free of disease for the duration of observation (over 3 years). In contrast, during the same period, the control animals progressed to disease. Both the vaccinees and the controls developed robust cell-mediated antiviral and neutralizing antibody responses following infection. A comparative analysis of these responses suggests that the more effective long-term control of infection by the vaccinated animals is due to the more rapid development of anti-HIV envelope antibodies. These studies suggest that priming by vaccination of B cell anti-HIV envelope responses maybe crucial for the long-term control of HIV infection.
- Subjects :
- CD4-Positive T-Lymphocytes
DNA immunization
Time Factors
Receptors, CCR5
Simian Acquired Immunodeficiency Syndrome
Priming (immunology)
HIV Antibodies
Macaques
Antibodies
ΔV2gp140
Viral Envelope Proteins
Immunity
Virology
medicine
Animals
Neutralizing antibody
B cell
Glycoproteins
AIDS Vaccines
Recombination, Genetic
B-Lymphocytes
SHIVSF162P4
biology
CD8+ depletion
Vaccination
virus diseases
HIV envelope protein
Macaca mulatta
HIV neutralization
medicine.anatomical_structure
Immunity, Active
Immunology
Vaccines, Subunit
CTL
biology.protein
HIV-1
Simian Immunodeficiency Virus
Antibody
CD8
Subjects
Details
- ISSN :
- 00426822
- Volume :
- 320
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Virology
- Accession number :
- edsair.doi.dedup.....4b1339d129ceed2f1d5b8fb14765cf7a
- Full Text :
- https://doi.org/10.1016/j.virol.2003.12.003