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The association of HMGB1 expression with clinicopathological significance and prognosis in hepatocellular carcinoma: a meta-analysis and literature review
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 10, p e110626 (2014)
- Publication Year :
- 2014
-
Abstract
- BackgroundHepatocellular carcinoma (HCC) is the fifth most common cancer, and it is the second most common cancer-related mortality globally. The prognostic value of high mobility group box 1 (HMGB1) remains controversial. The purpose of this study is to conduct a meta-analysis and literature review to evaluate the association of HMGB1 expression with the prognosis of patients with HCC.MethodsA detailed literature search was made in Medline, Google Scholar and others for related research publications. The data were extracted and assessed by two reviewers independently. Analysis of pooled data were performed, Hazard Ratio (HR) and mean difference with corresponding confidence intervals (CIs) were calculated and summarized respectively.Results10 relevant articles were included for this meta-analysis study. HMGB1 mRNA levels in HCC were significantly higher than those in normal (pConclusionsThe results of this meta-analysis suggest that HMGB1 mRNA and protein tissue levels in the patients with HCC are significantly higher than those in para-tumor and normal liver tissues respectively. Tissue HMGB1 overexpression is a potential biomarker for HCC diagnosis, and it is significantly associated with the prognosis of patients with HCC.
- Subjects :
- Oncology
medicine.medical_specialty
Carcinoma, Hepatocellular
Colorectal cancer
Science
MEDLINE
chemical and pharmacologic phenomena
Gastroenterology and Hepatology
Bioinformatics
Disease-Free Survival
Metastasis
Internal medicine
Carcinoma
medicine
Biomarkers, Tumor
Medicine and Health Sciences
Humans
HMGB1 Protein
Survival rate
Neoplasm Staging
Multidisciplinary
business.industry
Liver Diseases
Liver Neoplasms
Cancer
Hepatocellular Carcinoma
medicine.disease
digestive system diseases
Neoplasm Proteins
Gene Expression Regulation, Neoplastic
Survival Rate
Hepatocellular carcinoma
Meta-analysis
Medicine
business
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....4b01073e91628e6be532e413d1bcb8ea