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Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases
- Source :
- Cellular Physiology and Biochemistry, Vol 47, Iss 4, Pp 1319-1337 (2018)
- Publication Year :
- 2018
- Publisher :
- S. Karger AG, 2018.
-
Abstract
- High mobility group box-1 (HMGB-1), a typical damage-associated molecular pattern protein released from various cells, was first identified in 1973. It is usually stored in the nuclei of cells. Several modifications of HMGB-1 promote its translocation to the cytosol, and it is actively or passively released from cells. When outside of the cells, HMGB-1is crucial in inflammation. It exerts its biological functions via interaction with its receptors, including receptor for advanced glycation end products (RAGE) and Toll-like receptor 4(TLR4). A large number of studies showed a close link between inflammation and thrombosis. This review demonstrated the increased expression of HMGB-1 in thrombosis-related diseases, including coronary artery disease, stroke, peripheral arterial disease, disseminated intravascular coagulation, and venous thrombosis. Besides, it summarized the current understanding of the emerging link between HMGB-1 and thrombosis from three aspects: platelet, NETs, and coagulation and fibrinolysis factors. Finally, it explored the possible therapeutic strategies targeting HMGB-1 for treating thrombosis-related diseases.
- Subjects :
- Blood Platelets
0301 basic medicine
Physiology
medicine.medical_treatment
Receptor for Advanced Glycation End Products
Inflammation
Disseminated intravascular coagulation
Bioinformatics
Extracellular Traps
Coronary artery disease
lcsh:Physiology
RAGE (receptor)
lcsh:Biochemistry
03 medical and health sciences
Venous thrombosis
Peripheral arterial disease
Fibrinolysis
medicine
Animals
Humans
lcsh:QD415-436
Platelet
HMGB1 Protein
HMGB-1
lcsh:QP1-981
business.industry
Thrombosis
medicine.disease
Toll-Like Receptor 4
Stroke
030104 developmental biology
TLR4
medicine.symptom
business
Subjects
Details
- ISSN :
- 14219778 and 10158987
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Cellular Physiology and Biochemistry
- Accession number :
- edsair.doi.dedup.....4af07868c5a5ee137484f8c5edd5cad6