Capsaicin-induced neurogenic inflammation in pig skin: A behavioural study

Authors :: Mette S. Herskin
Lars Jelstrup Petersen
Pierpaolo Di Giminiani
Source :: di Giminiani, P, Petersen, L J & Herskin, M S 2014, ' Capsaicin-induced neurogenic inflammation in pig skin: A behavioural study ', Research in Veterinary Science, vol. 96, pp. 447-453 . https://doi.org/10.1016/j.rvsc.2014.03.023, Di Giminiani, P, Petersen, L J & Herskin, M S 2014, ' Capsaicin-induced neurogenic inflammation in pig skin : A behavioural study ', Research in Veterinary Science, vol. 96, no. 3, pp. 447-453 . https://doi.org/10.1016/j.rvsc.2014.03.023
Publication Year :: 2014
Publisher :: Elsevier BV, 2014.
Abstract: Topical capsaicin is a well-established model of experimental hyperalgesia. Its application to the study of animals has been limited to few species. The effect of topical capsaicin on hyperalgesia in porcine skin was evaluated as part of a study of inflammatory pain in the pig. Two experiments were carried out on pigs of 27 ± 5 kg (n = 8) and 57 ± 3 kg (n = 16). Thermal and mechanical noxious stimuli were provided (CO2 laser and Pressure Application Measurement device) to assess avoidance behaviours. Capsaicin induced significant thermal hyperalgesia in the smaller pigs (P