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Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis
- Source :
- Chemical Communications. 57:1097-1100
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- A series of glycoside-peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis of cancer cells. More importantly, it exhibited liver cancer cell-targeting behavior due to the galactose-asialoglycoprotein receptor recognition.
- Subjects :
- Lipid Bilayers
Antineoplastic Agents
Apoptosis
Peptide
Ion Channels
Catalysis
chemistry.chemical_compound
Cell Line, Tumor
Materials Chemistry
Humans
Moiety
Ion transporter
chemistry.chemical_classification
Ion Transport
Gramicidin
Metals and Alloys
General Chemistry
Transmembrane protein
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry
Cancer cell
Ceramics and Composites
Biophysics
Peptides
Conjugate
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....4adccc41cb1e92fa7b1b050e9a395b2e