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Characteristics in gut microbiome is associated with chemotherapy-induced pneumonia in pediatric acute lymphoblastic leukemia
- Source :
- BMC Cancer, BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
- Publication Year :
- 2021
-
Abstract
- Background Children with acute lymphoblastic leukemia (ALL) undergoing chemotherapy experience a relatively high risk of infection. And the disturbance of gut microbiota is generally believed to impair intestinal barrier function and may induce bacterial infections and inflammation. The study aimed to investigate the alterations in the gut microbiota and assess its relationship with chemotherapy-induced pneumonia in pediatric ALL patients. Methods We conducted a case–control study with 14 cases affected by pneumonia and 44 unaffected subjects and characterized the physiological parameters and gut microbiota by microarray-based technique. Results There were significant differences in α- and β-diversity in the affected group compared with the control group. At species level, the LEfSe analysis revealed that Enterococcus malodoratus, Ochrobactrum anthropi and Actinomyces cardiffensis were significantly abundant in the affected subjects. A receiver operating characteristic (ROC) curve yielded the area under the curve (AUC) of 0.773 for classification between the two groups. In addition, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in the bacterial secretion system were more enriched in the affected group than in the control group. Conclusions Gut microbiota alteration was associated with chemotherapy-induced pneumonia in pediatric ALL patients, which provided a new perspective on the personalized clinical care of pediatric ALL.
- Subjects :
- Male
Cancer Research
Ochrobactrum anthropi
Microarray
Adolescent
Chemotherapy-induced pneumonia
medicine.medical_treatment
Antineoplastic Agents
Gut flora
Enterococcus malodoratus
Feces
Genetics
Medicine
Humans
KEGG
Child
RC254-282
Chemotherapy
Gut microbiome
biology
business.industry
16S rRNA quantitative microarray
Area under the curve
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Induction Chemotherapy
Pneumonia
Precursor Cell Lymphoblastic Leukemia-Lymphoma
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Oncology
Case-Control Studies
Immunology
Dysbiosis
Female
Pediatric acute lymphoblastic leukemia
business
Research Article
Subjects
Details
- ISSN :
- 14712407
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC cancer
- Accession number :
- edsair.doi.dedup.....4abd03dad1d71b51fe774a9c4de68e10