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Acetylcholine-induced whealing in cholinergic urticaria – What does it tell us?
- Source :
- Journal of Dermatological Science. 103:10-15
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Cholinergic urticaria (CholU) is characterized by the occurrence of itchy wheals induced by sweating. Intradermal injections of acetylcholine (ACh) have been proposed to help with diagnosing CholU and subgrouping of patients, but controlled studies are largely missing.To compare the rates of positive ACh test results in well characterized CholU patients and controls and to identify clinical features of CholU linked to ACh reactivity.Acetylcholine was injected intradermally into 38 CholU patients and 73 matched healthy controls. Wheal and flare skin responses were assessed after 15 and 30 min and correlated with clinical features of CholU.At 15 min after intradermal injections of ACh, wheal and flare responses were significantly more frequent in CholU patients than healthy controls, wheals: 34 % vs.15% (P = 0.028); flares: 50 % vs.18 % (P0.001). Also, wheals were 37 % and flares 172 % larger and of longer duration in CholU patients than in healthy controls (both P0.01). CholU patients with ACh-induced wheals (AChIntradermal ACh testing does not allow for the identification of CholU patients due to its low sensitivity. ACh-induced wheals, in patients with CholU, is linked to sweating and longer lasting symptoms. Intradermal ACh testing is an interesting tool for mechanistic studies in CholU.
- Subjects :
- Adult
Male
0301 basic medicine
Injections, Intradermal
Urticaria
Cholinergic Agents
Wheal and flare
Sweating
Dermatology
Controlled studies
Sensitivity and Specificity
Biochemistry
SWEAT
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
medicine
Humans
In patient
Cholinergic urticaria
Molecular Biology
Skin
Skin Tests
integumentary system
business.industry
Middle Aged
medicine.disease
Acetylcholine
Healthy Volunteers
030104 developmental biology
Case-Control Studies
Anesthesia
Feasibility Studies
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 09231811
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Journal of Dermatological Science
- Accession number :
- edsair.doi.dedup.....4ab009885186f0cdb15974104f160928