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On the relationship status for Arf and NPM1 - it's complicated
- Source :
- The FEBS journal. 285(5)
- Publication Year :
- 2018
-
Abstract
- Arf levels are tightly regulated in cells and correlate with the level of ribosome biogenesis and proliferative status of cells. Through multivalent interactions with NPM1 - a regulator of ribosome biogenesis, and Mdm2 - a regulator of cellular fate, Arf integrates within the nucleolar matrix, altering its structure, dynamics and function and therefore modulates the cell cycle.
- Subjects :
- 0301 basic medicine
biology
Chemistry
Nucleolus
Regulator
Ribosome biogenesis
Nuclear Proteins
Proto-Oncogene Proteins c-mdm2
Cell Biology
Cell cycle
Biochemistry
Cell biology
03 medical and health sciences
030104 developmental biology
Tumor Suppressor Protein p14ARF
biology.protein
Mdm2
Nuclear protein
Molecular Biology
Nucleophosmin
Function (biology)
Cell Nucleolus
Cyclin-Dependent Kinase Inhibitor p16
Subjects
Details
- ISSN :
- 17424658
- Volume :
- 285
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The FEBS journal
- Accession number :
- edsair.doi.dedup.....4aaed0c76a88d97f9a69c483ea2558a6