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Cortical sulcal enlargement in catatonic schizophrenia: a planimetric CT study
- Source :
- Psychiatry Research: Neuroimaging. 91:45-54
- Publication Year :
- 1999
- Publisher :
- Elsevier BV, 1999.
-
Abstract
- To determine whether patients with catatonic schizophrenia have specific alterations in brain morphology, internal (ventricles) and external (frontal, temporal, parieto-occipital) components of the cerebrospinal fluid (CSF) spaces were examined morphometrically. Planimetric measurements of computed tomographic (CT) scans from 37 patients with catatonic schizophrenia, 28 patients with hebephrenic schizophrenia, and 39 patients with paranoid schizophrenia, all diagnosed according to DSM-III-R criteria, were compared with separate age- and sex-matched non-psychiatric control groups, respectively. The areas of the frontal sulci, the parieto-occipital sulci, the inter-hemispheric fissure, and the lateral and third ventricles were measured separately for the right and left hemispheres. Catatonic patients showed significant enlargements in almost all CSF spaces, especially in the left fronto-temporal area which, in addition, correlated significantly with illness duration. Hebephrenic patients showed selective enlargements in left temporal and left/right lower frontal cortical sulci, whereas paranoid schizophrenic patients showed no enlargements but significant correlations between left temporal cortical sulcal volume and illness duration. Alterations in temporal cortical areas were present in all three sub-types of schizophrenia. In addition to temporal alterations, hebephrenic schizophrenia was characterised by lower frontal (i.e. orbitofrontal) enlargement. Catatonic schizophrenia, the most severe sub-type with regard to clinical symptomatology and brain pathology, showed fronto-parietal cortical alterations.
- Subjects :
- Adult
Male
Paranoid schizophrenia
Catatonia
Neuroscience (miscellaneous)
Illness duration
Catatonic Schizophrenia
Severity of Illness Index
behavioral disciplines and activities
Cerebral Ventricles
Cerebrospinal fluid
mental disorders
Severity of illness
medicine
Humans
Radiology, Nuclear Medicine and imaging
Dominance, Cerebral
Schizophrenia, Paranoid
Schizophrenia, Catatonic
Schizophrenia, Disorganized
Brain morphometry
Age Factors
Brain
Anatomy
Middle Aged
medicine.disease
Psychiatry and Mental health
Schizophrenia
Case-Control Studies
Multivariate Analysis
Female
Tomography, X-Ray Computed
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 09254927
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research: Neuroimaging
- Accession number :
- edsair.doi.dedup.....4aa159c80b7e84349ac78233383923a8