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Discriminative stimulus and reinforcing effects of p-fluoro-l-deprenyl in monkeys
- Source :
- Psychopharmacology. 182:95-103
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- para-Fluoro-l-deprenyl (Fludepryl), a halogenated derivative of l-deprenyl, shares structural similarities with amphetamine and may have potential as a medication for psychostimulant abuse. p-Fluoro-l-deprenyl was evaluated for psychomotor stimulant, discriminative stimulus, and reinforcing effects in squirrel monkeys. One group of monkeys was trained under a ten-response fixed-ratio (FR10) schedule of stimulus termination to discriminate between methamphetamine (0.32 mg/kg, i.m.) and saline. Other monkeys were trained to self-administer i.v. cocaine under either a simple FR10 schedule or a second-order fixed-interval 5-min schedule with FR10 components. Full generalization to the methamphetamine-training stimulus was produced by an i.m. dose of 10.0 mg/kg p-fluoro-l-deprenyl. l-Deprenyl and the metabolites of p-fluoro-l-deprenyl, p-fluoro-l-amphetamine, and p-fluoro-l-methylamphetamine were more potent, producing full generalization at doses of 1.0–3.2 mg/kg. Under the FR10 schedule of drug injection, persistent self-administration behavior was maintained by i.v. cocaine injections but not by injections of vehicle or injection doses of p-fluoro-l-deprenyl up to 1.0 mg/kg. However, p-fluoro-l-deprenyl did maintain moderate levels of i.v. self-administration responding under the second-order schedule of drug injection. Peak response rates maintained by 0.1-mg/kg injections of p-fluoro-l-deprenyl were significantly greater than those associated with saline substitution, yet significantly lower than those maintained by cocaine or d-amphetamine. p-Fluoro-l-deprenyl has methamphetamine-like discriminative-stimulus properties in squirrel monkeys that appear at higher doses than for its parent compound, l-deprenyl. It also appears to function as a relatively limited reinforcer of intravenous self-administration behavior in monkeys trained to self-administer i.v. cocaine.
- Subjects :
- Dextroamphetamine
Reinforcement Schedule
medicine.medical_treatment
Amphetamine-Related Disorders
Conditioning, Classical
Self Administration
Stimulus (physiology)
Pharmacology
Injections, Intramuscular
Methamphetamine
Discrimination Learning
Structure-Activity Relationship
Cocaine
Selegiline
medicine
Animals
Amphetamine
Saimiri
Motivation
Dose-Response Relationship, Drug
biology
business.industry
Amphetamines
Squirrel monkey
Association Learning
biology.organism_classification
Stimulant
Generalization, Stimulus
Injections, Intravenous
Central Nervous System Stimulants
Self-administration
Stimulus control
business
medicine.drug
Subjects
Details
- ISSN :
- 14322072 and 00333158
- Volume :
- 182
- Database :
- OpenAIRE
- Journal :
- Psychopharmacology
- Accession number :
- edsair.doi.dedup.....4a9ed776fde3f425370e0b3f78340587