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Exercise training combined with antioxidant supplementation prevents the antiproliferative activity of their single treatment in prostate cancer through inhibition of redox adaptation
- Source :
- Free Radical Biology and Medicine, Free Radical Biology and Medicine, 2014, 77, pp.95-105, Free Radical Biology and Medicine, Elsevier, 2014, 77, pp.95-105, Free Radical Biology and Medicine, Elsevier, 2014, 77, pp.95-105. ⟨10.1016/j.freeradbiomed.2014.09.009⟩, Free Radical Biology and Medicine, 2014, 77, pp.95-105. ⟨10.1016/j.freeradbiomed.2014.09.009⟩
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- In preclinical models, exercise training (ET) or pomegranate juice (PJ) prevents prostate cancer progression. Here, we hypothesized that physical exercise combined with antioxidants could induce synergistic effects through oxidative stress modulation. Forty male Copenhagen rats with prostate tumors were divided into four groups: control, PJ, ET, and PJ+ET. Rats from the PJ group consumed 750 µl of PJ daily, rats from the ET group ran on a treadmill 5 days per week, and PJ+ET rats received the combined treatment. Each week, tumor growth was evaluated. After 4 weeks of treatment, the rats were euthanized and blood, muscles, and tumors were collected. Tumor Ki67, extracellular signal-regulated kinase (ERK) activation, Bcl-2 expression, and enzymatic and nonenzymatic antioxidant defenses, as well as oxidative stress markers (oxidized base, lipid peroxidation, protein carbonylation), were measured. PJ or ET significantly decreased prostate tumor proliferation (Ki67 staining, p
- Subjects :
- Male
medicine.medical_specialty
Antioxidant
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Administration, Oral
Physical exercise
medicine.disease_cause
Biochemistry
Antioxidants
Lipid peroxidation
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Physiology (medical)
Internal medicine
Cell Line, Tumor
Physical Conditioning, Animal
TBARS
medicine
Animals
Extracellular Signal-Regulated MAP Kinases
Muscle, Skeletal
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
Whole blood
Cell Proliferation
Lythraceae
0303 health sciences
Kinase
Chemistry
Plant Extracts
Superoxide Dismutase
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Prostatic Neoplasms
3. Good health
Rats
Tumor Burden
Oxidative Stress
Endocrinology
030220 oncology & carcinogenesis
Fruit
Cancer cell
Disease Progression
Oxidation-Reduction
Oxidative stress
Neoplasm Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 08915849
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine, Free Radical Biology and Medicine, 2014, 77, pp.95-105, Free Radical Biology and Medicine, Elsevier, 2014, 77, pp.95-105, Free Radical Biology and Medicine, Elsevier, 2014, 77, pp.95-105. ⟨10.1016/j.freeradbiomed.2014.09.009⟩, Free Radical Biology and Medicine, 2014, 77, pp.95-105. ⟨10.1016/j.freeradbiomed.2014.09.009⟩
- Accession number :
- edsair.doi.dedup.....4a9e8615fb67e1c52086da18262bf34a